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IL-6 and its receptor in the pathogenesis of rheumatoid arthritis medicine treatment

Author: LinHong
Tutor: XiaoPeiGen；ShenBeiFen
School: Peking Union Medical College , China
Course: Pharmacognosy
Keywords: Osteoarthritis Monocytes Anti-rheumatic Synovial cells Culture supernatant Spleen cells Tripterygium glycosides Abnormal expression Signal transduction pathways Serum
CLC: R259
Type: PhD thesis
Year: 1998
Downloads: 184
Quote: 0
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Abstract


Rheumatoid Arthritis(RA) is a disease characterized by chronic polyarticular inflammation which mechanisms of pathogensis still remain unclear. The superproliferation of synoviocytes and destruction of articular cartilage were the major pathological properties. Interleukin 6 is a multifunctional cytokine and play an important role not only in the immunoresponse but also in the hematopoietic, neural and endocrine systems. It displays a wide variety of biological effects in numerous tissues and cells. IL-6 exerts its effects by binding to specific receptors on the target cell surface. The IL-6 receptor complex consists of two subunits: 80-kDa binding chain IL-6R and signal transducer gp130. The over-expression of IL-6 and its receptor has been reported in autoimmune diseases such as multiple myeloma(MM),systemic lupus erythematosus(SLE) and RA. A number of investigators have reported that there are detectably elevated level of interleukin 6(IL-6) and soluble IL-6 receptor(sIL-6R)in serum and synovial fluid of RA patients.However, the precise role of IL-6 and IL-6R in the aetiology and pathogenesis of RA remains unclear. The aim of this paper is to detect the expression of IL-6 and IL-6R in the arthritis rats and RA patients.The effects of Chinese herb on the expression of IL-6 and IL-6R in the arthritis rat are studied also.Firstly, type II collagen-induced arthritis (CII-A)in rats has been established successfully and compared with Freund’s complete adjuvant arthritis(A-A). The legs of the arthritis rats were taken and cut section for pathological examination. IL-6 and IL-6R mRNA expression were detected in the peripheral blood lymphocyte of rats by in situ hybridization using IL-6 and IL-6R probe which were labled by photobiotin. The activity of IL-6 and the level of sIL-6R in serum and spleen cell cultural supernatant of arthritis rat were measured. The results of pathological section showed

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