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Studies on a New Ophthalmic Route of Administration System with Puerarin

Author: WuChunJie
Tutor: HouShiXiang
School: Sichuan University
Course: Pharmacy
Keywords: Ophthalmic route of administration system pH triggered gelling Puerarin Borneol
CLC: R283
Type: PhD thesis
Year: 2005
Downloads: 494
Quote: 3
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The tendency of developing new dosage forms through ideal ocular administration is to improve the biopharmaceutical characters and to make drugs enter the target areas more accurately through expected paths. Nowadays, the common problems existing in the Ophthalmic drug delivery system include the short retention time of ordinary eye drops in conjunctival sac due to the fact that dacryma unceasingly excreted in conjunctival sac and is quickly removed through nasal canal, making the drugs difficult to permeate cornea and resulting in a low bioavailability in eyes. Another is the probability of producing pantosomatous adverse effect when the drugs get into gastrointestinal tract after expelling through the nasal canal. Consequently it is of great importance to increase the contact time between drugs and cornea.The consideration to prolong the corneal contact time and improve the corneal permeability of drugs curing the intraocular diseases was introduced in this investigation. Our investigation adopted puerarin as model medicine to prepare pH triggered ophthalmic Gelling for puerarin, in order to enhance the bioavailability of puerarin taken in ocular region. And we also investigated the bases of the proper formulation and practice of borneol, expecting to establish a new ophthalmic drug delivery system of puerarin. Accordingly, we did researches on relative aspects.We investigated hydroxypropyl-β-cyclodextrin (HP-β-CD) on the aqueous solubility, stability and in vitro corneal permeation of puerarin for the purpose of preparing pH Triggered ophthalmic Gelling for puerarin and solving the problems such as color deepening in physic liquor, poor stability and bioavailability, its difficulties in preparing new gel with Carbopol, etc. when solubilizing puerarin.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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