Dissertation > Excellent graduate degree dissertation topics show

Hardening Protein in the Metal （Au,Ag） and Oxide （Fe3O4,CoO,and CeO2） Nanoparticles Corona

Author: LiFangYi
Tutor: GaoChaoHui
School: Jilin University
Course: Biological Engineering
Keywords: nanobiology metallic oxide nanoparticles
CLC: R318.0
Type: Master's thesis
Year: 2013
Downloads: 12
Quote: 0
Read: Download Dissertation

Abstract


Study of the molecular characteristics of inorganic nanoparticles (NPs) is anexpanding fi eld of research that focuses on the use of different NP conjugates fordiagnosis and therapy in medicine. NPs dispersed in biological fl uids are sensitive tosuch an environment and suffer modifi cations. The surface modifi cations of metaland metal oxide nanoparticles with sizes ranging from7to20nm dispersed incommonly used cell culture medium supplemented with serum are investigated. Allthe tested nanoparticles adsorb proteins onto their surface, thereby forming a proteincorona through a dynamic process evolving towards an irreversible coating (hardprotein corona). Despite the fact that the studied nanomaterials have similarcharacteristics of hydrophobicity and surface charge, different temporal patterns ofthe protein corona formation are observed that can be considered a fi ngerprint fornanoparticle identifi cation. Some of the biological and toxicological implications ofthe formation of the nanoparticle–protein corona are studied using the humanmonocytic cell line THP-1exposed to cobalt oxide nanoparticles. Results show thatproduction of reactive oxygen species is decreased if the nanoparticles arepreincubated for48h with serum.

Related Dissertations

  1. Preparation and Bioavailability Evaluation of Fenofibrate Nanosuspension,R944
  2. Electroporation Assisted Surface-enhanced Raman Spectroscopy for Living Cells,R318.51
  3. Water-soluble hypocrellin / titanium dioxide dosing system and its properties of,TQ460.1
  4. A New Method for Thrombin Detection by Using Aptamers and Gold Nanoparticles,Q55
  5. Study on Electrochemistry and Raman Spectrum of Picoline Electro-Oxidation Beavior in Non-aqueous System,O626.321
  6. Inorganic filler of the modified polylactic acid,TQ320.1
  7. Complex functions drug-loaded microspheres and in spinal cord injury treatment Application of,R943
  8. Cyclodextrin -modified magnetic nanoparticles synthesis and study drug carrier,TQ460.1
  9. Cyclosporine A nanoparticles fibroin - PVA hybrid film former research,R943
  10. Nano LaFeO 3 Controllable Synthesis and TiO 2 bridged construct composite photocatalyst,O643.36
  11. Study on the Effect of Gold Nanoparticles in the Immunological Response Induced by Lipopolysaccharide,R318.08
  12. Study on Fluorescent Europium Nanoparticles and Their Application in Immunoassay and the Development of Functional Bitter Melon Beverage,TS275
  13. Preparation and Characterization of Fluorescent Carbon Nanoparticles and Their Application in the Cell Labeling,TB383.1
  14. Studies on Magnetic Nanocomposite Particles as Drug Carriers for Photodynamic Therapy Agents,TB383.1
  15. Organic/Inorganic Hybird Nanoparticles Modified Via Surface-Initiated Living Radical Polymerization,TB383.1
  16. The Application of Ordered Mesoporous Carbon and Glod Nanoparticles Composite in Bioensor,TB383.1
  17. Templated Synthesis of Surface Enhanced Raman Scattering Substrate and Its Application,O657.37
  18. The Synthesis, Assembly, and Property of Core-shell Structured Noble Metal Nanomaterials,TB383.1
  19. Fabrication of TiO2 and MoO3 Nanowires Based Sensor,TB383.1
  20. Prepartion and Applicatons of Novel Flurescent Mesoporous Nanoparticles,TB383.1
  21. Preparation and Characterization of Poly(ionic Liquids)/Pt Nanoparticle Hybrids,O643.36

CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues
© 2012 www.DissertationTopic.Net  Mobile