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The Hyperthermia and Imaging of Nanoparticles Modified by Deoxyglucose and Polyethylene Glycol

Author: WangYun
Tutor: DingZuo
School: Shandong University
Course: Materials Science
Keywords: Fe3O4 targeting effect magnetic induction hyperthermia magneticresonance imaging
CLC: R318.08
Type: Master's thesis
Year: 2013
Downloads: 33
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Abstract


The magnetic nanoparticle has various applications in the biomedical field, one of which may be used as the tumor hyperthermia material magnetic induction and magnetic resonance imaging (MRI) contrast enhancer. By applying the targeting technology to the integration technology of tumor clinics as its theoretical foundation, this study tries to take the deoxyglucose as the targeting molecule, which has great potential and advantages in and clinical applications and researches of magnetic nano-based media. The expectations of this study aims at integrating the tumor targeting technology, the magnetic induction hyperthermia therapy, and the magnetic resonance imaging detection. Meanwhile, a series of effect of cancer-targeted therapy can be thus motivated, providing a functional hyperthermia medium as well. The processes of the study are illustrated as follows:1. Fe3O4particles are synthesized by co-precipitation method and oxidation precipitation method. Morphology of the material structure and their properties of these two methods are compared by the TEM, XRD and VSM test. Nano-particles prepared by the former method are smaller (each about10nm or so). They are seriously reunioned, with the saturation magnetization of68.8emu/g, and are not well-crystallized. Nanoparticles prepared by latter method have a larger size (preferably about100nm), which are preferably crystallized and dispersed, with a saturation magnetization of84.5emu/g. After sufficient contrast, the oxidation precipitation method is thus applied in order to prepare Fe3O4nanoparticles as the magnetic nuclear material for the following procedures.2. By modifyng Fe3O4particles with silica, using the hydrolysis method, a synthesis of core-shell Fe3O4@SiO2magnetic material is composed. This silica shell is relatively thin tested through the TEM. A silicon-oxygen bond characteristic peak contained in the material is detected by the FTIR test, proving that the modification of silica is successful. And the VSM test shows that the magnetic of this material is rarely decreased. Meanwhile, the modification improves the stability of the material and so that it can obtain better modifier on aminosilane. In the further step, by introducing the3-aminopropyl triethoxysilane to the surface of the Fe3O4@SiOi, the amino silane is successfully modified on the surface of the composite magnetic particles with the free amino group, according to the TGA. XPS and FT1R test. After deoxy-glucose polyethylene glycol NHS esters react to form an amide bond and the amino group on the magnetic particles after the synthesis of magnetic particles with a target functional group. By thermal gravimetric analysis and infrared testing indicates that the material modification deoxyglucose and polyethylene glycol, the magnetic material has a long cycle of targeting and in vivo.3. This test deoxyglucose and polyethylene glycol-modified magnetic particles magnetic induction hyperthermia effect warming by comparing different concentrations and different magnetic field, shows that the modified materials not only have a warming effect, and can affect the temperature rise by changing the concentration or the magnetic induction intensity. which can be temperature-controlled magnetic induction of hyperthermia. Were tested oxide precipitation and coprecipitation method FC3O4particles and deoxyglucose polyethylene glycol-modificd magnetic particles MRI T2imaging performance. Found that the three materials have the T2-weighted imaging contrast enhancement oxide precipitate prepared Fe3O4particle effects, followed by the modified magnetic particles. Modified composite analysis, with deoxyglucose is not only targeting the accumulation of material in tumor cells can be achieved, and the Fe3O4both hyperthermia dielectric material can also be as T2-weighted magnetic resonance imaging contrast enhancers, this material can be a very good treatment and diagnosis of the tumor together achieve the integration of the cancer clinic.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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