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The Synthesis and Performance Study on Magnetic β-cyclodextrin Nano-composite

Author: CaoLiYan
Tutor: ShuangShaoMin
School: Shanxi University
Course: Pharmaceutical Analysis
Keywords: Magnetic nanoparticles Cyclodextrin Nanocomposite Package in cooperation with
CLC: TB383.1
Type: Master's thesis
Year: 2011
Downloads: 75
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Abstract


Chapter: a brief introduction to the characteristics of the magnetic nanoparticles in biomedical applications, synthesis and surface modification; overview of the characteristics of cyclodextrin and its derivatives, and its cooperation with the drug package; ring paste fine / magnetic nano-particles complex research progress. Chapter II: The the layers assembled synthesis β-CD/Fe3O4 magnetic nanocomposites. First by chemical co-precipitation method Fe304 magnetic nanoparticles were synthesized using orthogonal experiment method to optimize the preparation conditions. Then use the gum arabic to the surface modification of the magnetic nanoparticles modified particles having a good stability and biocompatibility and have a reactive functional group. Finally, the citric acid-modified p-CD with magnetic nanoparticles combine, form β-CD/Fe3O4 magnetic nano composite. X-ray diffraction (XRD), transmission electron microscopy (TEM), particle size analyzer (DLS), infrared spectroscopy (FTIR), and thermal gravimetric analysis (TGA) characterization methods to characterize them. Confirmed Fe304 magnetic nanoparticles to the grafted p-CD, according to the thermal gravimetric analysis curve estimated magnetic nano-particles the surface of the p-CD of about 83.1mg / g, and that each Fe304 magnetic nanoparticles combined with about 138 β-CD molecules. Chapter III: The main body HP-β-CD/Fe3O4 magnetic nanocomposite SBE-β-CD/Fe3O4 magnetic nanocomposite synthesis. First, p-CD with 1,4 - butanesultone nucleophilic substitution reaction to obtain the SBE-β-CD, combined with FTIR, and nuclear magnetic resonance spectroscopy confirmed the SBE-β-CD, derived degree of substitution of about 2.4. Citric further modified SBE-β-CD and HP-of β-CD dehydration condensation the obtained SBE-β-CD/Fe3O4 and HP-β-CD/Fe3O4 magnetic nano-composite body, the magnetic nanoparticles modified with gum arabic. DLS, FTIR and TGA characterization methods to the analysis of nano-composite body. Intuitive by the particle size analysis can be seen that the fluid dynamics of the nano composite average particle diameter is less than the magnetic nanoparticles of the modified gum arabic, while close to the fluid dynamics of Fe304 nm average particle diameter. According to FTIR and TGA inferred HP-β-CD and SBE-β-CD/Fe3O4 nano composite body was successfully synthesized, to estimate the amount of HP-β-CD of the surface of the magnetic nanoparticles to 54.8mg / g, i.e. each Fe304 magnetic nano the particle surface of HP-β-CD is 62; surface of magnetic nanoparticles SBE-β-CD in an amount of 71.8mg / g, i.e. the number of SBE-β-CD of the surface of the single Fe304 magnetic nanoparticles 93. Chapter 4: CD/Fe3O4 magnetic nanocomposites with non-steroidal anti-inflammatory drug ibuprofen inclusion. By UV-visible absorption spectroscopy, the determination of the amount of the inclusion of a β-CD/Fe3O4 magnetic nanocomposite, HP-β-CD, and SBE-β-CD/Fe3O4 magnetic nanocomposites ibuprofen, draw the biggest package together Cover were 7.39mg / g, 3.12mg / g, 10.25mg / g. Phase solubility method nanocomposite CD/Fe3O4 magnetic effect on the solubilization of ibuprofen inclusion after varying degrees, SBE-β-CD/Fe3O4 magnetic nanocomposite most significant effect solubilization of ibuprofen. Experimental conditions under β-CD/Fe3O4 magnetic nanocomposites HP-β-CD/Fe3O4 magnetic nanocomposites SBE-β-CD/Fe3O4 magnetic nano-complex of ibuprofen solubilization 8.14 times, 3.64 times, 38.88 times.

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