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Assembling Photosensitive Capsules by Phthalocyanines and Polyelectrolytes for Photodynamic Therapy

Author: ZengZuo
Tutor: TaoXia
School: Beijing University of Chemical Technology
Course: Chemical Engineering and Technology
Keywords: Aluminum phthalocyanine Self-assembled microcapsules Photodynamic Therapy
CLC: R318.51
Type: Master's thesis
Year: 2011
Downloads: 24
Quote: 0
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Abstract


Photosensitive microcapsules aluminum phthalocyanine (AlPcS4Cl) the photosensitizer and polyelectrolyte based on the principle of unlike charges attract alternating AlPcS4Cl and PAH adsorbed on precast hollow microcapsules build . Hollow microcapsules is built on the PSS - doped inorganic calcium carbonate template polyelectrolyte PAH and PSS assembly through the layers of self-assembly technique . Microcapsules having a size and thickness, can be controlled in the internal cavity of the load material and the function of the microcapsule wall such characteristics . In the the capsules walls of immobilized optical response of the material given the new features of the capsule and try to study the photodynamic therapy . Phthalocyanine photosensitizer load in the microcapsules on the photosensitive microcapsules formed system used in photodynamic therapy on cancer cells , and for The photosensitive microcapsules systems to study the mechanism of the generation of reactive oxygen species ( singlet oxygen ) and singlet oxygen phototoxicity little research . Hollow microcapsule AlPcS4Cl successful immobilization of the detection method of the UV absorption spectra and AFM Spectrum To confirm , while maintaining the photosensitivity of the photosensitizer and the ability to generate singlet oxygen . Meanwhile , we also found that in the process of preparation of photosensitive microcapsules , photosensitive microcapsules always maintained a spherical . In the irradiation of visible light (670 ± 10 nm) , the photosensitive microcapsules to produce cytotoxic singlet oxygen . The photosensitive microcapsules System detected by two methods : generating singlet oxygen with the capture agent TEMP or ABDA each reacted to generate a stable compound and can be recognized by the the ESR detection means and chemical detection method of singlet oxygen generated by the photosensitive microcapsules and studied singlet oxygen generation mechanism and phototoxicity . Can be drawn in in vitro experiments , photosensitive microcapsules showed good biocompatibility and cell lethality ; in MCF-7 breast cells role in the process , and free AlPcS4Cl compared photosensitive microcapsules showed a higher cell killing rate . From these results , we can think of photosensitive microcapsules is a safe photosensitizer carrier, has potential applications in photodynamic therapy .

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > Other branches of biomedical engineering > Light,laser biomedical
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