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Evaluation of the efficacy of comprehensive intervention of traditional Chinese medicine in treating hypertension

Author: FanLei
Tutor: ZhangYan
School: Liaoning University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: Hypertension susceptible cohort to hypertension Chinese medicineintervention evaluation of curative effect quality of life
CLC: R259
Type: Master's thesis
Year: 2012
Downloads: 62
Quote: 0
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PurPose:To study the curative effects and influence on life quality ofintegrated Chinese medicine intervention on lowering blood pressure andimproving symptoms of patients with hypertension and susceptible cohort tohypertension, by abserving them after integrated treatments of “Jumingparticle” decoction, combined with ear-acupoints sticking method and magneticbeads compression,which based on intervention of life style.Material and method:Patients with hypertension and susceptible cohort tohypertension aged from thirty to sixty-five were chosen as object of research,a prospective randomized, multicenter, large sample clinical trial was adopted.Subjects received dietary structure adjustment, Modified individualized“exercise prescription”, ear-acupoints sticking method and magnetic beadscompression for eight weeks, followed by observation every three months in ayear.The amplitude of decreasing blood pressure and effect time were evaluated.The curative effect, security and influence on life quality were evaluated aswell.Results:1.The level of blood pressure were compared before and after intervention:Comparing intervention group with control group,SBP and DBP of both groupsdecreased, there was statistical significance (P<0.05); comparing SBP ofintervention group with control group after treatment, there was greaterdecrease amplitude in intervention group than control group, there wasstatistical significance (P<0.05); comparing DBP of intervention group withcontrol group after treatment, there was no statistical significance(P>0.05).2. The effective rate of two groups are compared: In intervention group ninecases were significantly effective, thirty-six cases were effectual andtwenty-four cases were unfruitful with a total effective rate of65.22%; In control group three cases were significantly effective, twenty-nine cases wereeffectual and thirty-eight cases were unfruitful with a total effective rateof45.71%,The results indicated that intervention group and control group bothdecreased the level of blood pressure, there was statistical significance (P<0.05),but the effective rate of intervention group was higher than controlgroup.3. The amplitude of decreasing blood pressure in different time during thetreatment were compared: During observation period of one,two,four,eight weeksafter treatment, in the first week the amplitude of decreasing SBP was comparedwith control group, there was no statistical significance(P>0.05); in thesecond,fourth,eighth weeks the amplitude of decreasing SBP were greater thancontrol group,there was statistical significance(P<0.05); in the first,second,fourth,eighth weeks the amplitude of decreasing DBP were compared with controlgroup,there was no statistical significance(P>0.05).4. The effective rate of improving symtoms before and after intervention werecompared: In intervention group fourteen cases were significantly effective,thirty-seven cases were effectual and eighteen cases were unfruitful with atotal effective rate of73.91%. In control group seven cases were significantlyeffective,eighteen cases were effectual and fourty-five cases were unfruitfulwith a total effective rate of35.71%.The results indicated that the effectiverate of intervention group was higher than control group, there was statisticalsignificance (P<0.05).5. The clinical symptom score of two groups were measured before and afterintervention: After treatment the symptom score of two groups decresed comparedwith before treatment, there was statistical significance (P<0.05); thedifference value of two groups before and after treatment were compared, therewas statistical significance (P<0.05), which indicated intervention group hadbetter effect on improving clinical symptoms than control group. 6. The major symptoms of two groups were compared before and after treatment:Comparing symptoms of intervention group before and after treatment,there weregreat improvement in symptoms of dizzy giddy、headache、bitter mouth、sleepless、constipation,there was statistical significance (P<0.05); there were nosignificant improvement in symptoms of irritability、feverish sensation in chest,palms and soles、lumbar debility、palpitation、forgetfulness, there was nostatistical significance(P>0.05). Comparing symptoms of control group beforeand after treatment,there were great improvement in symptoms of dizzy giddy、headache、lumbar debility、dry mouth、sleepless,there was statisticalsignificance (P<0.05); there were no significant imprvoment in symptoms ofirritability、feverish sensation in chest, palms and soles、bitter mouth、constipation、palpitation、forgetfulness, there was no statistical significance(P>0.05).After treatment there was significant difference between two groupsin symptoms of dizzy giddy、headache、constipation、sleepless(P<0.05); therewas no significant difference between two groups in symptoms of irritability、lumbar debility、feverish sensation in chest, palms and soles、dry mouth、bittermouth、palpitation(P>0.05).7.The total score of life quality in all dimensions were compared: There wereno significant difference between two groups in eight dimensions after treatment(P>0.05). Among eight dimensions of life quality scores before and aftersixty-nine cases were treated with integrated intervention,there was nosignificant difference in Physiological Function(PF)、Mental Health(MH)、Vitality(VT)、General Heath(GH)(P>0.05); there were significant differencesin Physiological Role(RP)、Emotional Role(RE)、Body Pain(BP)、Social Function(SF)(P<0.05).Among seventy cases in control group, there were significantdifferences in Emotional Role(RE)(P<0.05), there was no significant differencein the other dimensions(P>0.05). Conclusion:1.Obvious effect of decreasing blood pressure was observed after treated withChinese medicine integrated intervention. SBP and DBP of intervention groupdecreased significantly after treatment;In terms of curative effect on SBP, theamplitude of decreasing SBP in intervention group was greater than control group,there was significant difference; In terms of curative effect on DBP, there wasno significant difference between two groups.2.During the observation period of one,two,four,eight weeks after Chinesemedicine intervention treatment,in the first week there was no significantdecrease of SBP in intervention group, there was no significant differencecompared with control group; In the second,fourth,eighth weeks significantdecrease in SBP were observed in intervention group, and there were significantdifference compared with control group; In the first,second,fourth,eighth weeksthere were no significant difference in DBP between two groups.3. Chinese medicine integrated intervention could improve symptomsefficiently,which had better curative effect than control group. It wasindicated that there was greater improvement in symptoms of dizzy giddy、headache、sleepless and constipation in intervention group than control group;there was no significant difference in symptoms of irritability、lumbar debility、feverish sensation in chest, palms and soles、dry mouth、bitter mouth andpalpitation between two groups.4.There was no significant difference in dimensions of Physiological Function、Mental Heath、Vitality and General Heath; there was significant difference indimensions of Physiological Role、Emotional Role、Body Pain、Social Function,which indicated Chinese medicine integrated intervention could improve lifequality of patients efficiently.

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