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Expelling Blood Circulation to Fill Around the Hematoma Fine Pulp on Experimental Cerebral Hemorrhage in Rat Brain Tissue Nerve Growth Factor and Its Receptor Expression

Author: RenHongLiang
Tutor: ZhaoJianJun
School: Changchun University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Intracerebral hemorrhage NGF TrkA poxuehuayu tianjingbusui chuxuexingzhongfengfang
CLC: R277.7
Type: Master's thesis
Year: 2012
Downloads: 54
Quote: 0
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Abstract


Purpose: Nerve growth factor (NGF) is a neurotrophic factor family (NTFs) leadingmember of the neuronal survival, neurotrophic factors not only regulate the developmentprocess and can prevent brain tissue damage due to neuron death in many neurological systemfunctions. That the function of nerve growth factor receptor TrkA, a combination of both, youcan activate tyrosine kinase signaling system, leading to activation of cell function, resultingin biological effects. This experiment used to study and compare the expelling bloodcirculation, replenishes the marrow of experimental intracerebral hemorrhage in ratsperihematoma nerve growth factor and its receptor TrkA expression. Hemorrhagic stroke inthe medical treatment to a new theoretical model for expelling blood circulation, replenishesthe marrow treatment of hemorrhagic stroke clinical treatment to build a mature experimentalscience framework, to further improve the the TCM brain theory of experimental learningmaterial.Methods: pure126Wistar rats of clean grade, half male and half female, weighing250-300g, were randomly divided into six groups, the establishment of a normal group of sixrats; low dose of the sham operation group, model group, and hemorrhagic stroke side group,a hemorrhagic stroke prescription dose group, and hemorrhagic stroke side high dose group.Experiments using rat brain stereotactic technique to establish a rat model of intracerebralhemorrhage from the body and tail arterial injection, the sham operation group after theneedle to the intracerebral injection of saline50ul, the needle for30min; the other four groupsnot to target brain bleeding lesions into anticoagulation in arterial blood from the body andtail of50ul of the needle for30min. The normal group without any disposal of S&P foodfeeding under the same conditions. Different groups after the modeling and1d,3d,7d,14dwere sacrificed. Observation of the rats with intracerebral hemorrhage lesion surroundingbrain tissue NGF and its receptors TrkA of pathological change.Results:(1) hemorrhagic stroke treated group can increase the expression of NGF and itsreceptor TrkA protein, a significant difference compared with cerebral hemorrhage modelgroup, low-dose group, significant sexual differences, p <0.01;(2) hemorrhagic stroke beforeto improve the animal models of neurological score, neurological deficit situation is significantly improved compared with the cerebral hemorrhage model group, suggesting thatChinese medicine after the intervention groups, a significant sex difference, p <0.05.Conclusion:(1) hemorrhagic stroke treated group can increase the expression of NGFand its receptor TrkA protein, a significant difference compared with cerebral hemorrhagemodel group, low-dose group, significant sexual differences, p <0.01;(2) hemorrhagic strokebefore to improve the animal models of neurological score, neurological deficit situation issignificantly improved compared with the cerebral hemorrhage model group, suggesting thatChinese medicine after the intervention groups, a significant sex difference, p <0.05.

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