Dissertation > Excellent graduate degree dissertation topics show

Role of CXCR3and Its Ligand I-TAC in the Pathogenesis of Immune Thrombocytopenic Purpura

Author: ZhangXiang
Tutor: FengJianMing; LiZhanQuan; XuCunHe; CuiSen
School: Qinghai University
Course: Internal Medicine
Keywords: Purpura thrombocytopenic idiopathic Interferon type Ⅱ CXCR3 I-TAC
CLC: R392
Type: Master's thesis
Year: 2012
Downloads: 18
Quote: 0
Read: Download Dissertation


Objective To investigate the roles and significance of the chemokine receptorCXCR3and its ligand I-TAC in the pathogenesis of immune thrombocytopenicpurpura (ITP) and to make clear their levels after immunosuppresive therapy.Methods A total of48ITP patients were enrolled in this study:30with newlydiagnosed or relapse ITP and18in remission after treatment, as well as24healthyvolunteers as controls. Gamma interferon (IFN-γ) and I-TAC in the plasma weredetected by enzyme-linked immunosorbent assay (ELISA). The mRNA expression ofCXCR3in the peripheral blood mononuclear cell (PBMNC) was determined byquantitative real-time polymerase chain reaction (RT-PCR).Results The IFN-γ level in the plasma of ITP patients before the treatment(71.45±17.62pg/ml) were obviously increased than those in the remission group(36.9±14.9pg/ml)and the normal controls(25.28±12.85pg/ml)(all P<0.05), andthose in remission group was higher than those in the controls (P<0.05). In contrast,the levels of I-TAC, there were no statistic difference among patients before thetreatment of ITP(455.56±144.700pg/ml) and remission group(488.24±164.70pg/ml) and the healthy controls(382.97±167.43pg/ml)(P>0.05). Both ITP patientsbefore the treatment(M6.76)(3.03,37.00)and remission groups(M1.76)(0.45,14.18)expressed more CXCR3mRNA (P<0.05). After effective therapy, CXCR3mRNA expression decreased, while it was still higher than those in the controls(M0.12)(0.04,0.28)(P<0.05).Conclusions Our data demonstrated that Th1cytokine (IFN-γ) dominance wasreflected in ITP. Simultaneously, the CXCR3~+cell may play a role in cell-mediatedimmunity through chemotaxis in ITP. In addition to above, this axis is influenced byimmunosuppresive therapy.

Related Dissertations

  1. The Clinical Observation of Curative Effect Made by Differential Treatment of Refractory Thrombocytopenic Purpura,R259
  2. Clinical Observation on HSPN of the Thermal Damaged Blood Type of Collaterals with Zidian Decoction,R259
  3. Go through the academic thought and clinical experience and treatment of allergic purpura clinical research,R249.2
  4. Research of the Different Syndrome Type of Idiopathic Thrombocytopenic Purpura to Glucocorticoid Sensitive Rate,R259
  5. Effect of Yiqi Huayu Recipe on Treatment of Allergic Purpura Nephritis Clinical Curative Effect Observation,R277.5
  6. Investigation of the Immunopathogenesis of Henoch-Schonlein Purpura,R554.6
  7. Preliminary Study of the MRI Diagnosis and Differential Diagnosis in Multiple System Atrophy , Progressive Supranuclear Palsy and IPD,R445.2
  8. The Study of Clinical Chracteristics and Pathogenesis of Thrombotic Thrombocytopenic Purpura,R554.6
  9. Changes of the Metalloprotease That Cleaves Von Willebrand Factor in Women During Normal Pregnancy and Other Diseases Like Gestational Hypertension,R714.25
  10. Treatment by Cyclosporin A in Idiopathic Membranous Nephropathy: a Meta-analysis,R692.3
  11. Correlation of Single Nucleotide Polymorphisms of NPR3 Gene and COL11A2 Gene with Idiopathic Short Stature,R723
  12. Construction of Mouse CXCR3A and Human CXCR3B Gene Transfected Cell Lines, Identification and Study of Their Biological Functions,R730.3
  13. The Changes of Serum Levels of Ghrelin and IGF-1 in Idiopathic Short Stature Children and Their Relationship with Helicobacter Pylori Infection,R723
  14. Clinical Research of Montelucast for the Treatment of Children with Allergic Purpura,R725.6
  15. Intravitreal injection of Bevacizumab treatment of idiopathic choroidal neovascularization lesion,R773.4
  16. Function of Th17 Cells and Change of CD4~+CD25~+T Regulatory Cells in Children with Henoch-Schonlein Purpura in Acute,R725.5
  17. Human cytomegalovirus infection and childhood idiopathic thrombocytopenic purpura clinical analysis,R725.5
  18. The Relationship between SDF1 Expression Upregulated in the Human Typeⅱ Alveolar Epithelium by Hypoxia and HIF1 or HIF2,R363
  19. Mutations in Nr5a1, PIN1 Associated with Idiopathic Hypogonadotropic Hypogonadism,R588
  20. Long-Term Observation of Girls with Idiopathic Central Precocious Puberty Treated with GnRH Analogs: Impacts on Height and Body Mass Index,R725.8
  21. Response to Lower Dose Rituximab Therapy for Immune Thrombocytopenic Purpura,R558.2

CLC: > Medicine, health > Basic Medical > Medical Immunology
© 2012 www.DissertationTopic.Net  Mobile