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Role of CXCR3and Its Ligand I-TAC in the Pathogenesis of Immune Thrombocytopenic Purpura

Author: ZhangXiang
Tutor: FengJianMing; LiZhanQuan; XuCunHe; CuiSen
School: Qinghai University
Course: Internal Medicine
Keywords: Purpura thrombocytopenic idiopathic Interferon type Ⅱ CXCR3 I-TAC
CLC: R392
Type: Master's thesis
Year: 2012
Downloads: 18
Quote: 0
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Abstract


Objective To investigate the roles and significance of the chemokine receptorCXCR3and its ligand I-TAC in the pathogenesis of immune thrombocytopenicpurpura (ITP) and to make clear their levels after immunosuppresive therapy.Methods A total of48ITP patients were enrolled in this study:30with newlydiagnosed or relapse ITP and18in remission after treatment, as well as24healthyvolunteers as controls. Gamma interferon (IFN-γ) and I-TAC in the plasma weredetected by enzyme-linked immunosorbent assay (ELISA). The mRNA expression ofCXCR3in the peripheral blood mononuclear cell (PBMNC) was determined byquantitative real-time polymerase chain reaction (RT-PCR).Results The IFN-γ level in the plasma of ITP patients before the treatment(71.45±17.62pg/ml) were obviously increased than those in the remission group(36.9±14.9pg/ml)and the normal controls(25.28±12.85pg/ml)(all P<0.05), andthose in remission group was higher than those in the controls (P<0.05). In contrast,the levels of I-TAC, there were no statistic difference among patients before thetreatment of ITP(455.56±144.700pg/ml) and remission group(488.24±164.70pg/ml) and the healthy controls(382.97±167.43pg/ml)(P>0.05). Both ITP patientsbefore the treatment(M6.76)(3.03,37.00)and remission groups(M1.76)(0.45,14.18)expressed more CXCR3mRNA (P<0.05). After effective therapy, CXCR3mRNA expression decreased, while it was still higher than those in the controls(M0.12)(0.04,0.28)(P<0.05).Conclusions Our data demonstrated that Th1cytokine (IFN-γ) dominance wasreflected in ITP. Simultaneously, the CXCR3~+cell may play a role in cell-mediatedimmunity through chemotaxis in ITP. In addition to above, this axis is influenced byimmunosuppresive therapy.

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