Dissertation > Excellent graduate degree dissertation topics show

A Preliminary Investigation on Morphologic Basis of Left Ventricular Systolic Strain Characteristics with Agingin Spontaneously Hypertensive Rat

Author: LinDongMei
Tutor: RuanQinYun
School: Fujian Medical
Course: Medical Imaging and Nuclear Medicine
Keywords: spontaneously hypertensive rat myocardial strain myocardial remodeling aging
CLC: R445.1
Type: Master's thesis
Year: 2013
Downloads: 2
Quote: 0
Read: Download Dissertation


Background and ObjectivePrevious studies on left ventricular strain in patients with essential hypertension have indicated by our group that systolic longitudinal strain decreased in the early stage, and multidimensional strain was affected later. But the morphological basis of this progression is still unclear. This study was aimed to investigate left ventricular systolic strain and morphology changes with aging in spontaneously hypertensive rat (SHR) by using two-dimensional strain echocardiography(2DSE).Method6012-week-old male SHR confirmed with hypertension by tail-cuff were randomly divided into6groups(n=8-10). Left ventricular hemodynamic and, echocardiagraphic paremeters and myocardial histology and ultrastructure was observed at12w,16w,28w,45w and66w respectively.2DSE measurements included SL, SR and SC of six segments of LV at papillary muscle level, and myocardial histology included myocyte diameter, CVF and PVCA by HE and Masson stain. The relationship between CVF, PVCA and SL were studied by correlation analysis.ResultCompared with12w group, the ventricular wall thickness, LVDd, LAD, LVM in28w,45w and66w groups were higher (p<0.05) especially in45w and66w groups. While E and E/A were significantly decreased only in66w (p<0.05), and LVEF and FS showed no difference between each group. On the contrary to LVEDP, which decreased with age and reached its minimum at28w, LV+dp/dt, LV-dp/dt and myocardial strain increased with age and reached its maximum at28w, than decreased (p<0.05),Cardiomyocytes diameter and PVCA indicated growth trend since16w, but only significantly increased in66w, compared to45w (p<0.05). And compared with12w and16w group, CFV increased in28w (p<0.05),45w (compared with28w, p>0.05) and66w (compared with45w,p<0.01) groups. CVF, PVCA and myocardial longitudinal strain showed negatively correlated (r=-0.503,-0.592; p=0.04,0.029). Cardiomyocyte hypertrophy, myofilament local dissolving, mtiochondra swelling and sporadic collagen fibers proliferation appeared from28w, and getting more obviously in66w group.Conclusion1. In12-16week, left ventricular myocardial systolic strain of SHR still remain in development stage, which may last till28week, when myocardial proliferation starts. So, it should be condidered to choose the time point of SHR in the related research.2. The myocardial remodeling, such as cardiomyocyte hypertrophy, collagen fibers proliferation and the thickness of vascular wall, progressed along with the aging of SHR, and reached its maximum at66week, which showed the same variation time-line as diastolic function.3Although, LVEF showed no significant change in28-66w, considering the damage of myocardial systolic strain, which correlated to the proliferation of collagen fibers, systolic function may be effected by reducing cellular oxygen supply.

Related Dissertations

  1. Chemical Structures and Mechanism Research of Anti-aging Leading Compounds from Natural Products,R285.5
  2. Maternal Exposure to Fenvalerate in Embryo Accelerated Age-related Changes of Behaviors in CD-1 Mice,R714.2
  3. Regulation of drugs on the Role of body balance,R96
  4. Aging Process and Reproductive Characters of Experimental Clones of Elymus Excelsus in the Songnen Plains of China,S812
  5. Preparation and Characterization of EVA Film for Encapsulanting PV Modules,TB383.2
  6. Effect of Age-related Changes of Gap Junction Protein on Ventricular Arrhythmia in Rats,R541.7
  7. The Anti-Aging Function of Curcumin and Essential Fatty Acids,R285.5
  8. The Regulation and Research of Mechanism of "Plus Sijunzi Decoction" in Immune System of the Aging Rat,R285.5
  9. Protein Structure Prediction with Improved Quantum Immune Algorihm,O413;TP301.6
  10. First - principles calculations and molecular dynamics simulations of the aging precipitation of CuCr alloys,TG166.2
  11. Mg-Al alloys of early aging process of analysis and the first principles and molecular kinetics of,TG156.92
  12. Parameters and aging on platelet activation markers and the impact of intervention,R543
  13. Effects of Telmisartan and Pyridoxamine on Artery Smooth Muscle Cell Proliferation and Apoptosis in Spontaneously Hypertensive Rats,R544.1
  14. The Study of Interventional Effect of Jiaweitianmagou-tengyin Decoction on the Early Hypertensive Renal Damage and Vascular Endothelial Dysfunction of SHR,R285.5
  15. Induction of Klotho Gene Expression by Natural Product Compounds and the Anti-aging Analysis,R285
  16. Aging Changes of PPARĪ± in Rat Hepatic and the Effect of Atorvastatin,R589.2
  17. The Basic Research of Properties of All-ceramic Restoration Bonded by Resin Cement and Color Properties of the Resin,R783.1
  18. Effect of Rice Bran Antioxidant Peptides on Mitochondria Damage in Aging Mice Induced by D-galactose,R96
  19. SBR modified asphalt emulsion and its nano- SiO_2 composite modified asphalt emulsion research,U414
  20. Investigation on Japan's foreign workers policy,DD912.5
  21. Research on Index of Asphalt Mixture Water Stability Testing Based on the Strength Theory,U414

CLC: > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Ultrasonic diagnosis
© 2012 www.DissertationTopic.Net  Mobile