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Association between Obstructive Sleep Apnea Syndrome and Nonalcoholic Fatty Liver Disease

Author: MaWanYong
Tutor: LiNanFang
School: Xinjiang Medical University
Course: Internal Medicine
Keywords: obstructive sleep apnea syndrome (OSAS) nonalcoholic fatty liver disease（NAFLD） association studies
CLC: R766
Type: Master's thesis
Year: 2013
Downloads: 1
Quote: 0
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Abstract


Objective To investigate the relativity of nonalcoholic fatty liver diseas（eNAFLD）andobstructive sleep apnea syndrome (OSAS). Methods：1693patients were randomlyrecruited from2005to2009from in-hospital hypertensive patients,which were checked byPSG in our Sleep Center.841patients were diagnosised to fatty liver and another852were diagnosised to without fatty liver by B ultrasound. The subjects underwentpolysomno-graphy and according to apnea-hypopnea index(AHI) they were divided intofour groups To discuss some indices between the two groups, including age、gender、abdominal girth、body mass index (BMI)、apnea hypopnea index (AHI)、lowest arterialoxygen saturation（lowest SaO2）、total cholesterol (TC)、triglyceride (TG)、high densitylipoprotein cholesterol (HDL-C)、low density lipoprotein cholesterol (LDL-C)、fastingblood-glucose（FBG) and analysis the relevant risk factors of fatty liver. Results①Gender、Age、AHI、Lowest-SaO2、TC、TG、LDL-C、FBG、ALT、LDH andα-HDBHhad significant differences between OSAS group and NON-OSAS group (P<0.05).②Patients in severe OSAS group had higher detection rate of NAFLD than the other threegroups.(P<0.05);③Multivariate logistic regression suggested that AHI、BMI、FBG、TC、TG/HDL-c were risk factors of fatty live（rP＜0.05）. Conclusions The proportion of fattyliver is52%in OSAHS, in no-OSAHS, the proportion is41%. AHI、Age、BMI、FBG、TC、 TG/HDL-c could probably affect the fatty liver;OSAHS may through thestrengthening of insulin resistance and oxidative stress induced fatty liver.

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