Dissertation > Excellent graduate degree dissertation topics show

Study of Cord Blood Angiotensin Ⅱ in the Offspring of Mothers with Gestational Diabetes Mellitus

Author: ZhangFeng
Tutor: ZhangXia
School: Chongqing Medical University
Course: Internal Medicine
Keywords: metabolic syndrome insulin sensitivity gestational diabetesmellitus angiotensin Ⅱ
CLC: R587.1
Type: Master's thesis
Year: 2012
Downloads: 13
Quote: 0
Read: Download Dissertation

Abstract


BackgroundOffspring of mothers with gestational diabetes mellitus (GDM) are prone to develop metabolic syndrome (MetS) later in life. Angiotensin Ⅱ (Ang Ⅱ) is an important component of renin-angiotensin system. In addition to the regulation of cardiovascular function, Ang Ⅱ is also strongly associated with insulin sensitivity, diabetes and MetS. But there is no study about the cord blood Ang Ⅱconcentration and its relationship to fetal insulin sensitivity in offspring of mothers with GDM.ObjectiveTo determine cord blood Ang Ⅱ concentration and assess its relationship to fetal insulin sensitivity in the offspring of mothers with GDM at birth.MethodsThirty women with GDM and30healthy women were evaluated at elective cesarean delivery. Cord blood was obtained for measurement of Ang Ⅱ, glucose and insulin. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated and used to estimate fetal insulin sensitivity. Ponderal index (PI) was used to estimate fetal adiposity. ResultsThe GDM group had higher PI, HOMA-IR, cord blood Ang Ⅱ and insulin concentrations than normal glucose group. In all the offspring, cord insulin concentration and HOMA-IR were positively associated with PI, whereas not associated with maternal pre-pregnancy BMI, late pregnancy BMI, blood pressure, fetal sex and gestational age. In GDM group, cord Ang Ⅱ concentration was positively associated with HOMA-IR, whereas not associated with maternal pre-pregnancy BMI, late pregnancy BMI, systolic blood pressure, diastolic blood pressure, birth weight, PI and cord blood glucose concentration.Conclusions(1) The offspring of mothers with GDM has higher cord blood concentration of insulin and Ang Ⅱ and lower insulin sensitivity at birth.(2) Fetal hyperinsulinemia/decreased insulin sensitivity is associated with fetal adiposity in the offspring of mothers with GDM.(3) Increased cord Ang Ⅱ concentration is associated with decreased insulin sensitivity in the offspring of mothers with GDM.

Related Dissertations

  1. Shamisen Medicinal and Edible Herbs on glucose and lipid metabolism in the metabolic syndrome and antioxidant effects,R285.5
  2. The One-year Efficacy After Short-term Insulin Pump Treatment in Newly Diagnosed Type 2 Diabetes,R587.1
  3. Study of Relationship between Metabolic Syndrome and Benign Prostatic Hyperplasia,R697.3
  4. A Comparison of the Metabolic Syndrome Score and the Framingham Risk Score for Prediction of Cardiovascular Disease,R589
  5. Comparison of the Different Diagnostic Criteria for the Metabolic Syndrome among University Staff in Shenyang,R589
  6. The Effect of Trimethyl-apigenin in Metabolic Syndrome Mice Due to Intervention of Monosodium Glutamate and Overnutrition During Lactation,R589
  7. Relationship of Serumγ-glutamyl Transpeptidase with Metabolic Syndrome in Elderly People,R589
  8. Hyperglycemia in patients with metabolic syndrome and changes in coagulation and fibrinolysis system mechanism of rosiglitazone,R589
  9. Elderly Population in Changshan People’s Hospitalmedical and Epidemiological Survey of Metabolic Syndrome Related Factors,R181.3
  10. Relationship between the Prevalence Study of Peripheral Artery Disease and Metabolic Syndrome among the Uygur Kazakh and Han Adults Lived in Xinjiang,R589
  11. Serum 25-hydroxy Vitamin D Level in Diabetic Patients and Its Effect on Blood Glucose and Bone Mass,R587.1
  12. Study of Factor Analysis of Metabolic Syndrome and the Influencing Factors on Metabolic Sydrome in Male Police,R589
  13. The Epidemiological Survey of Non-alcoholic Fatty Liver Disease in Health Checkup People in Chaoshan Region,R575.5
  14. Evaluation of Plasma LOX-1 and Adiponectin Level in Coronary Artery Disease Patients Accompanied with Metabolic Syndrome,R541.4
  15. Of tea polysaccharide of glucose and lipid metabolism , metabolic syndrome rats and Mechanism,R285.5
  16. Effects of Zi Yin Qing Xin Decoction on the Expressions of Inflammatory Factor C-reactive Protein in Patients with Metabolic Syndrome,R259
  17. STEAP4 gene in human adipocyte differentiation and regulation of the expression of factors of,R723.14
  18. The Relation of Serum Leptin, Adiponectin and the Metabolic Syndrome in Obese Adolescents,R723
  19. Acssociation Research between Interleukin-6 Promoter-174G/C and C-reactive Protein (CRP)+1059G/C Polymorphism with Metabolic Syndrome in Xinjiang Kazakh and Han,R589
  20. The Study of Vascular Damage and Relation Research in Patients with Metabolic Syndrome,R589
  21. Effect of Tetrandrine on Arterial Baroreflex Function in Sinoaortic Denervated Rats,R285.5

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile