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Effects of Aerobic Exercise on the Expression of the Visfatin Gene and Protein in Obesity Rat Adipose Tissue

Author: ShangGuanZuo
Tutor: FengFeiHu
School: Wuhan Institute of Physical Education
Course: Sports Medicine
Keywords: Aerobic endurance exercise high fat diet visceral adipose tissue fat visfatin
CLC: G804.2
Type: Master's thesis
Year: 2012
Downloads: 112
Quote: 0
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Objective:Long-term aerobic ran a movement observation to the fat rat lipid levels and visceral fat tissue visfatin gene and protein expression level influence and discuss the possible mechanism, to provide a theoretical basis for the motion to reduce weightMethods:By four weeks of age60male Sprague-Dawley rats were randomly divided into two groups, control group10:general feeding, high fat diet group50. Respectively using common feed and high fat feed for feeding. After high fat feeding7weeks founding obesity model in16rats, and then they were randomly divided into two groups (n=8):obesity does not exercise group (OW), obesity exercise group (OW-E), the beginning of the eighth week of exercise intervention. During treadmill exercise, all rats were fed with common feed. Combining exercise with the nutrition intervention group exercise program:a rat for electric treadmill, the slope of5degrees, the speed of15.2m/min, a64+4.5%VO2max strength, and electric drive. Exercise duration of60minutes,6times per week, Sunday rest, lasted eight weeks. In the last training session and after12hours of fasting, the rats with2%sodium pentobarbital intraperitoneal anesthesia, blood from the heart, isolated from the serum, quickly removed perirenal adipose tissue and testis of perirenal fat tissue and weighing, with aluminum foil wrap, plunged into liquid nitrogen frozen, then transferred to-80degrees C refrigerator. Statistical analysis using the13edition of SPSS statistical software. The results for" mean+SD"(x+s) said. Statistical analysis using the single factor analysis of variance and independent sample t test. P<0.05is expressed as significant difference, P<0.01is shown as a very significant difference.Result:1. High fat diet can induce experimental rats happen simple obesity, and cause dyslipidemia.2. Visfatin express degree:Control group significantly (P<0.05) less than OW, OW group-group E significantly (P<0.05) less than OW group.3. Internal fat mass:OW group of internal fat mass higher than group C, has a very significant difference (P<0.01); OW-E group internal fat content significantly lower than OW group (P<0.05).4. Three group of big lies in fat tissue protein level visfatin no significant difference (P>0.05).5. Internal fat tissue visfatin mRNA gene expression quantity and internal fat positive correlation between quantity (r=0.48, P<0.05).Conclusion:1:High fat diet can induce experimental rats happen simple obesity, and cause dyslipidemia.2. Big lies inside adipose tissue visfatin mRNA expression of visceral fat with the increase of number and visceral fat volume a positive correlation (r=0.48, P<0.05).3. Long-term aerobic exercise significantly reduced visceral fat tissue visfatin mRNA expression (P<0.05); But for internal fat tissue protein expression level visfatin has no significant effect (P>0.05).4. Long-term aerobic exercise can reduce high fat feed of rats induced obesity of serum TG (P<0.05), increase HDL-C (P<0.05), so as to improve blood lipid levels.

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