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The Correlation Studies of GFR Evaluated by Equations and Renal Dynamic Imaging
Author: RenYing
Tutor: SangXiaoHong
School: Xinjiang Medical University
Course: Internal Medicine
Keywords: chronic kidney disease Glomerular filtration rate Estimation equation
CLC: R692
Type: Master's thesis
Year: 2012
Downloads: 27
Quote: 0
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Abstract
Objective:To analyze the difference between CKDEPI equation and simplifiedMDRD equation using to evaluate GFR and explore the applicability of CKDEPIequation in patients with chronic kidney disease（CKD）,under the reference standard ofGlomerular filtration rate（sGFR） measured by^{99m}TCDTPA renal dynamicimaging.Methods:A total of308patients with CKD which were hospitalized and checkedby the method of^{99m}TCDTPA renal dynamic imaging between January and December2010were selected for the detection of serum creatinine（Scr） level and GFR wereestimated with CKDEPI equation and simplified MDRD equation separately.To analyzethe correlation between eGFR and sGFR,and the difference the bias,accuracy andprecision of eGFR evaluated by the two equations.Results:Linear regression analysisshowed that the correlation coefficients between eGFR and sGFR of simplified MDRDequation and CKDEPI equation were0.818and0.839（P=0.000）.There was significantdifference between eGFR and sGFR of the two equations（P＝0.005）.The bias of eGFRevaluated by CKDEPI equation was lower0.96ml·min^{1}·（1.73m^{2}）1than eGFR evaluatedby simplified MDRD equation.eGFR evaluated by CKDEPI equation of15%,30%,50%accuracy was28.90%,53.57%,75.32%and eGFR evaluated by simplified MDRD equationof15%,30%,50%accuracy was27.27%,54.22%,76.95%.There were no difference ofaccuracy both in the whole and in different stages of the kidney function.In CKD1stage,the bias of simplified MDRD equation is greater. BlandAltman analysis theconsistency showed that when sGFR≧60ml·min^{1}·（1.73m^{2}）1,the bias was smaller,theprecision was higher of CKDEPI equation.Conclusion:There is significant differencebetween eGFR evaluated by CKDEPI equation and simplified MDRD equation andsGFR measured by^{99m}TCDTPA renal dynamic imaging.CKDEPI equation showescertain advantages in earlier stage.However,there is some limitation in our research,so whether there is difference between simplified MDRD equation and CKDEPI equationactually needs more studies.

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CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Kidney disease
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