Dissertation > Excellent graduate degree dissertation topics show

The Studies on Clinical Value of AFP-L3%Detected by Microspincolum Method for Judgment of Treatment Response in Patients with HCC Undergoing TACE

Author: ZhouXiang
Tutor: PanHongMing
School: Zhejiang University
Course: Oncology
Keywords: alpha-fetoprotein AFP Lens culinaris agglutinin-reactivealpha-fetoprotein AFP-L3 hepatocellular carcinoma HCC Curative effectprediction
CLC: R735.7
Type: Master's thesis
Year: 2013
Downloads: 2
Quote: 0
Read: Download Dissertation

Abstract


Objective:The study is aimed to examine the pre-operative and post-operative levels of alpha-fetoprotein (alpha-fetoprotein, AFP) and AFP heterogeneity (Lens culinaris agglutinin-reactive alpha-fetoprotein, AFP-L3) for patients with TACE treatment, to determine the relationship between the variation of the serum AFP-L3%, of AFP level and the efficacy of TACE surgery, and to explore the clinical value of AFP-L3%for HCC patients after TACE treatment.Methods:We collected from Run Run Shaw Hospital, Zhejiang University School of Medicine and The Sixth People’s Hospital of Hangzhou,28liver cancer cases with the TACE treatment and complete clinical data. All cases show positive AFP(>20ng/ml). After the separation of all serum, samples were frozen under-80℃in a ultra-low-temperature refrigerator. The variation in the tumor volume and the deposition of iodized oil were used as the judging criteria for efficacy, we use micro-centrifuge column method for the AFP-L3separation, and compare TACE surgery level of the pre-and post-operation. We employ the statistical analysis to the corresponding data.The results:All patients studied here had received TACE surgery. Based on changes in tumor volume evaluation criteria (RECIST criteria),28patients were divided into effective group and ineffective group, which has24patients and4ones respectively. Males predominate in both groups, This difference was not statistically significant (P>0.05). The average age for the patients in the effective group is lower than that of the ineffective group, but this difference is statistically meaningless (P>0.05).Among24effective patients,1week after TACE surgery, AFP level for9cases declines, AFP-L3%level for19cases declines. However,1month after TACE surgery, AFP level for14cases declines, AFP-L3%level for21cases declines. The difference between the two groups was statistically significant (P<0.05).Conclusions:The variations of AFP-L3%after HCC TACE treatment show different features compared to that of AFP. AFP-L3%decline forecast more meaningful with TACE efficacy compared to that of AFP, especially in the early (after1week) more advantages. Therefore, post-operative AFP-L3level is a significant independent factor for determining the TACE curative effect.

Related Dissertations

  1. Cloth and β- elemene combined administration of anti-tumor effect and mechanism of celecoxib,R96
  2. Clinical Significance of STAT3 and MMP-2 in Hepatocellular Carcinoma.,R735.7
  3. Assessment of Efficicy of Transarterial Chemoembolization by Gelfoam Particles Using DSCT Perfusion Imaging for Hepatocellular Carcinoma,R735.7
  4. Gelatin Sponge Particles Embolization of Hepatocellular Carcinoma after Regulatory T Cells and Its Significance,R735.7
  5. Quantiative Proteomics of Liver Immortalized Cell Line Chang Liver and Liver Cancer Cell Line HepG2,R735.7
  6. Expression and Functional Role of Proton-regulated Channels in Hepatic Carcinoma Cells,R735.7
  7. The Anti-tumor Effects of Lupeol in Hepatocellular Carcinoma,R735.7
  8. The Expression of GPC3、 AFP、 HCG and CD34 in Hepatocellular Carcinoma,R735.7
  9. The Association of PTEN Gene with the Development of Hepatocellular Carcinoma,R735.7
  10. Association of β-transducin Repeat-containing Protein (β-TrCP) Genetic Polymorphisms with Hepatocellular Carcinoma Susceptibility and Its Functional Analysis,R735.7
  11. Dynamic Observation on the Plasma Level of Vascular Endothelial Growth Factor and Matrix Metalloproteinases in Advanced Hepatocellular Carcinoma Patients after Transarterial Chemoembolization Combined with Infusion of Endostar,R735.7
  12. Study of the Expression and Function of TC21/R-Ras2 in Hepatocellular Carcinoma,R735.7
  13. Anti-cancer Effect of Membrane Penetrating Peptide 11R in Oncolytic Adenoviruses Carrying P53,R735.7
  14. Meta Analysis of the Relationship between IL-6 or TNF-α and Human Primary Hepatocellular Carcinomas,R735.7
  15. The Assocation of Hepatitis B Virus Genotype and Bascal Core Protmoer Mutations with Liver Cirrhosis and Hepatocellular Carcinoma Risks in Southern Shandong Province,R512.62
  16. Killing-effect on Hepatocellular Carcinoma by AFP-regulated Oncolytic Adenvirus Carrying Manganese Superoxide Dismutase Gene,R735.7
  17. Detection of hTERT mRNA and GGT mRNA in the Peripheral Blood of Small HCC Patients and Its Clinical Significance,R735.7
  18. Whole Exome Capture Sequencing Identifies Candidate Genes Related to HCC,R735.7
  19. Qingdao region of hepatitis B virus the BCP gene mutation and hepatitis B virus associated with primary liver cancer,R512.62
  20. The Expression and Correlation of TGF-β1and E-cadherin in Hepatocellular Carcinoma,R735.7
  21. Significance of Protein and mRNA Expression of Tumor Suppressor Gene PLAGL1 in Human Hepatocellular Carcinoma,R735.7

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
© 2012 www.DissertationTopic.Net  Mobile