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Research on Toxin-removing, Blood-Activating and Phlegm-Removing Method in Treating Vascular Dementia

Author: LiHui
Tutor: WuZuoZuo
School: Nanjing University of Traditional Chinese Medicine
Course: Basic Theory of Traditional Chinese Medicine
Keywords: Qingdu blood phlegm Vascular Dementia Shuanggenqinnao particles Micro- associated protein Neural stem cells
CLC: R277.7
Type: Master's thesis
Year: 2011
Downloads: 62
Quote: 0
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Abstract


Vascular dementia (vascular dementia, VD) refers to cognitive impairment caused by ischemic or hemorrhagic stroke, or hypoxic-ischemic brain damage is characterized by chronic progressive disease. With the arrival of China's aging society, the increased incidence of cerebrovascular disease, vascular dementia incidence increased year by year, has been a serious threat to the health and lives of the elderly. In recent years, many Chinese scholars to explore traditional Chinese medicine therapy in the treatment of vascular dementia Recipe, made a good effect on the treatment of vascular dementia, but its therapeutic mechanism has not been fully elucidated, hindering the promotion of the use of traditional Chinese medicine in clinical. Therefore, it is active in Chinese medicine in the treatment of vascular dementia research has important practical significance. Mentor on the basis of long-term clinical and experimental studies, combined with modern Chinese medicine vascular dementia acute onset or fluctuation period of phlegm and blood, of hot poison staggering pathological key vascular dementia awareness and research, disinfection Huoxue The circulation for basic governance Treatment. This study, blood phlegm disinfection Dafa to establish Shuanggenqinnao particles (Shuanggen Qinnao Granules, SG) to intervene in the rat model of vascular dementia, and achieved good effect. From both theoretical and experimental aspects to investigate the mechanism of blood phlegm Qingdu treatment of vascular dementia. Theoretical study to explore the use of traditional Chinese medicine theory predilection for vascular dementia, the etiology and pathogenesis, therapeutic principle proposed Phlegm blocking the course of time, the heat of the poison damage brains is the acute phase of vascular dementia or volatility of the pathological key blood circulation and resolving disinfection treatment of this period Dafa, of and Shuanggenqinnao particles Prescription based side solution and treatment mechanism to explore. The experimental study consists of in vivo and in vitro experiments in two parts, from the behavior, morphology, raw chemical, cytological, molecular level to explore key to the pathology of vascular dementia acute phase of sputum, stasis, poison \The sputum Therapy mechanism of the vascular dementia modern pharmacology. TTC staining vascular dementia rat model of cerebral infarct volume overall experimental study, the results showed that: a group Shuanggenqinnao particles infarct volume was significantly smaller than the vascular dementia model rats (P lt; 0.05, P lt; 0.01 ), especially in small doses significantly (P lt; 0.01). By Morris water maze the rat spatial resolution and learning and memory ability compared with the model group, the rats in each group hidden platform Shuanggenqinnao particles obtained experimental time increased, the number of times per minute search platform, and the observed vascular dementia model statistically significant (P lt; 0.05). Dual-root Qingnao particles can increase the activity of SOD and SOD / MDA ratio (P lt; 0.01) lower MDA, NO content and NOS activity (P lt; 0.05, P lt; 0.01), so as to reduce the oxygen free radicals damage to the brain tissue. Found: double-root Qingnao particles in the low dose group of BrdU DCX, BrdU / DCX, three positive cells compared with the model group increased significantly (P lt; 0.05, P lt; 0.01); rat brain using immunohistochemical method the internal toxic products (vascular endothelial ICAM-1, the hippocampus nNOS positive nerve) increased, but Shuanggenqinnao particles ICAM-1 expression and nNOS positive neurons less than the model group (P lt; 0.05, P lt ; 0.01). By Westerblot; determination strong model of nNOS protein Shuanggenqinnao particles in the low dose group nNOS expression significantly reduced (P lt; 0.05). Measured by MTT assay the activity of the hypoxic state neural stem cells (NSCs) in vitro experimental study results showed that the the OD value Shuanggenqinnao particles are higher than the sham group, especially in doses significantly (P lt; 0.05) shows that Shuanggenqinnao particulate drug serum can promote neural stem cells live. Westerblot method hypoxic state NSCs of nNOS, the DCX protein results show that groups Shuanggenqinnao particles DCX protein were higher than the model group, but there was no significant difference (P gt; 0.05), while nNOS content are higher in the high-dose group was significantly (P lt; 0.01), hypoxia proliferation and differentiation of NSCs that Shuanggenqinnao particles can promote and improve the role of nNOS protection of NSCs. Conclusion: basic pathogenesis of vascular dementia acute phase or fluctuations of the characteristics of phlegm and blood stasis, the heat toxin; blood phlegm disinfection is the basic law for the treatment of vascular dementia. Double-root Qingnao particles can improve vascular dementia rat model of learning and memory capacity, clear \

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