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Background: The treatment of spinal cord injury (SCI) is a difficult clinical medicine . Although many scholars have made efforts in this area and explore , but still have not found a completely cured of this disease . With the development of science and technology , especially the in-depth study of the various stem cells (SCs) , our treatment of such diseases , a new way of thinking . Some researchers found that : the important role of the endogenous neural stem cells (ENSCs) SCI repair . As we all know : acupuncture treatment of SCI has a significant effect , but the mechanism is unclear . Some people think that acupuncture can promote the expression of endogenous neurotrophic factor (NTF) , example : brain-derived neurotrophic factor ( BDNF ) , nerve growth factor (NGF) . In addition, there are some studies found that the NTF , such as BDNF, basic fibroblast growth factor (bFGF) promoting ENSCs proliferation . Therefore , we assume : the acupuncture through promote ENSCs proliferation and orientation induced to differentiate into neurons to attain the repair of the injured spinal cord and nerve conduction function reconstruction . Objective : To observe the efficacy of acupuncture for spinal cord injury and to explore the mechanism for the treatment of spinal cord injury . Methods : 25 adult male SD rats were randomly divided into sham group (A group , n = 5 ) , injury group (B , n = 10) and injury after acupuncture treatment group (C group , n = 10 ) . A group does not damage the spinal cord , B and C groups modified Allen 's heavy objects fall strike law (25g cm) Preparation of a spinal cord injury model . Without any treatment ; Group B and C group were given acupuncture treatment , 1 / d , 7d for a course , a total of two courses . Two weeks later sacrificed distance Injury Center 5mm spinal cord immunohistochemical staining , detection of Nestin, Brdu NSE , GFAP expression . BBB score and neurological examination results : rats before in the drawn the expression of Nestin and Brdu , in group C than in group B was significantly ( P lt; 0.05) ; NSE expression in group C than in group B was significantly (P lt ; 0.05) ; of GFAP expression in group B than in group C was significantly (P lt; 0.05) . Group C BBB rated higher apparent recovery of neurological function . Conclusion : Acupuncture induce differentiation and promote its recovery of neurological function after spinal cord injury in rats endogenous neural stem cells .
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