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The purpose of the preterm children patent ductus arteriosus (PDA) occurred on the relationship between risk factors and serum cortisol levels and premature PDA. Methods January 2008 to December were retrospectively analyzed 751 cases of premature children in Fujian Province Maternal and Child Health Hospital neonatal inpatient, 48 patients were diagnosed PDA case group, 85 cases of non-PDA for the control group, two groups of clinical information control study group Logistic regression model for the analysis of risk factors; Second, the reference to the 1:1 matching nested case-control study, on the basis of univariate analysis, application, select the period January 2009 to December born 432 preterm children in Fujian Province Maternal and Child Health Hospital neonatology treatment cohort, the pre-acquired the radial artery, was born 3 days after the diagnosis of PDA cases, in accordance with similar gestational age (gestational age difference of less than 1 week), the same mother prenatal dexamethasone to promote fetal maturity history matching, select the same period in hospital the same day echocardiography to exclude PDA in preterm children as the control group, a total of 38 pairs of matching. Case and control groups collected clinical data, and the line echocardiography day again collected radial artery. Serum cortisol values ??detected by chemiluminescence, and the data were statistically analyzed using SPSS 13.0 software. Results in the retrospective analysis, univariate analysis showed that gestational age, birth weight, the mother prenatal hormone, fetal distress, oxygen, birth asphyxia, respiratory failure, hyaline membrane disease, sepsis, fluid intake, ultrasound echocardiography timing and occurrence of PDA in preterm children associated with, the OR was 2.636,2.755,0.311,12,0.431,3.692,3.038,7.085,2.282,1.026,0.474; Logistic regression analysis showed that small gestational age, low birth weight, birth asphyxia, sepsis is a major risk factor, the The OR values ??2.517,2.957,13.770,3.493 mother prenatal hormones, oxygen is the main protective factors, the OR value is 0.208 and 0.127. Nested case-control study: demographic characteristics and birth serum cortisol values ??influencing factors, no significant difference between the case and control groups (P are gt; 0.05) PDA group was born when serum cortisol concentrations the 9.49 ± 8.32μg/dl, while the control group was 13.76 ± 8.56μg/dl, the difference was statistically significant (P = 0.031). Logistic regression analysis showed that low birth serum cortisol levels is premature child PDA risk factors (OR = 0.916). PDA group and the control group, the second edge of the serum cortisol concentration estimated mean and 95% confidence intervals were in control of the birth of serum cortisol baseline values, hypoxia, infection, critically ill psychosis factors: 10.87μg / dl (8.42 ~ 13.31μg/dl), 9.55μg/dl (7.11 ~ 12.0μg/dl), two sets of calibration average, the difference was not statistically significant (P = 0.466). Conclusion preterm infants with PDA with perinatal variety of factors, small gestational age, low birth weight, birth asphyxia, sepsis, low serum cortisol levels of birth is a major risk factor for mothers with prenatal hormones, oxygen is the main protective factors . The occurrence of preterm children PDA does not affect the serum cortisol levels. Targeted for perinatal care is to reduce the effective measures of PDA in preterm children.
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