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Effect of Weight Training and Soybean Peptide Supplement on Myocardial Antioxidant Capacity of Rat in Aging Process

Author: JiaHua
Tutor: ZhaoBin
School: Hebei Normal
Course: Human Movement Science
Keywords: Weight training Soybean peptide Senescence Myocardial Antioxidant
CLC: R151
Type: Master's thesis
Year: 2010
Downloads: 71
Quote: 0
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Abstract


With the global increase in the elderly population in the world with varying degrees of aging, aging problem gradually by governments and social concerns. Aging process, heart earlier than other organs, appear degenerative changes in structure and function, serious impact on the health of the elderly, and free radical production and scavenging homeostasis break, is considered one of the important reasons of myocardial aging. Delaying myocardial many aging intervention, in which exercise, diet is the best. In this study, rats were injected with D-galactose copy subacute aging model, in six weeks modeling process, while applying weight training and supplement intervention soybean peptides observed aging serum and myocardial homogenates indicators of change, and to analyze its effects on Myocardial aging effect of antioxidant capacity, as the crowd soon accumulate some experiments the theoretical basis and experimental reference, but also for the elderly population in the effective promotion of the sport, reasonable and effective nutritional supplements and sports nutrition combined with The new method provides a theoretical basis and practical guidance. In this study, three-month-old healthy male SD rats were 56 for the study were randomly divided into 7 groups: adult control group (C), D-galactose model group (M), D-galactose small negative recombinant (S) , D-galactose large negative recombinant (B), D-galactose complement peptide group (P), D-galactose fill small negative recombinant peptide (SP) and D-galactose fill large negative recombinant peptide (BP). In addition to group C, the other groups in the six weeks modeling process, respectively treadmill weight training and supplement soybean peptides intervention. 6 weekends sacrificed to compare the serum and biochemical markers of myocardial homogenates. Results 1.6 weekend, compared with group C, M serum MDA content increased significantly (P lt; 0.05), SOD activity was a significant decrease (P lt; 0.01). 2.6 weekends, compared with group C, M group, myocardial tissue MDA, lipofuscin very significant increase (P lt; 0.01, P lt; 0.01). Weight training can make aging rat myocardial tissue MDA, lipofuscin content was significantly decreased (P lt; 0.05, P lt; 0.05); soy peptides can make aging rat myocardial tissue MDA, lipofuscin declining trend ( P gt; 0.05, P gt; 0.05), two kinds of interventions with significant or very significant interaction (P lt; 0.05, P lt; 0.01). 3.6 weekends, compared with group C, M group, myocardial tissue SOD, CAT, GSH-PX activity was a significant decrease (P lt; 0.01, P lt; 0.01, P lt; 0.01). Weight training or supplement soybean peptides were able to make the aging rat myocardial tissue SOD, GSH-PX activity increased significantly (P lt; 0.05, P lt; 0.05), two kinds of interventions have had significant interaction (P lt ; 0.05, P lt; 0.05). The weight training or supplement soybean peptides were able to make aging rat myocardial tissue CAT activity increasing trend appears (P gt; 0.05, P gt; 0.05), two kinds of intervention was significant interaction (P lt; 0.05). 4.6 weekend, compared with group C, M NO content in myocardial tissue was significant decrease (P lt; 0.01). Weight training or supplement soybean peptides are to make aging rat cardiac tissue NO levels were seen increasing trend (P gt; 0.05), two kinds of intervention was significant interaction (P lt; 0.05). 5.6 weekends, compared with group C, M group, myocardial tissue Na-K-ATPase and Ca2-Mg2-ATPase activity was a significant decrease (P lt; 0.01, P lt; 0.01). Weight training can make aging rat myocardial tissue Na-K-ATPase activity increased significantly (P lt; 0.05), while soy peptides can make aging rat myocardial tissue Na-K-ATPase activity appeared an increasing trend (P gt ; 0.05), two kinds of interventions with significant interaction (P lt; 0.05). Weight training or supplement soybean peptides can make aging rat myocardium Ca2-Mg2-ATPase activity was significant or significantly higher (P lt; 0.01, P lt; 0.05), two kinds of intervention was significant interaction (P lt; 0.05). Conclusions 1 through 6 weeks of D-galactose subcutaneously, model group, serum MDA content, SOD activity decreased myocardial tissue lipofuscin content increased, and the appearance of aging symptoms and behavioral changes, indicating that the aging of the experiment successful model. 2.6 weeks weight training or supplement soybean peptides were able to improve the aging rat varying degrees of myocardial antioxidant enzyme activity, reduce lipid peroxidation product formation; weight training combined with soy peptides, a significant interaction between the two together to further enhance the aging rat myocardial antioxidant capacity, which make up a small weight peptide group best, and anti-oxidation of more comprehensive performance, increased myocardial tissue SOD, CAT, GSH-PX activity and NO content and lower levels of MDA and lipofuscin content. 3.6 weeks weight training or supplement soybean peptides were able to improve the aging rat varying degrees of myocardial tissue Na-K-ATPase and Ca2-Mg2-ATPase; weight training combined with soy peptides, a significant interaction between the two, to further enhance the aging rats myocardial function activity, reduce free radical cell membrane damage, maintain cell membrane stability, enhanced ion transport, regulation of energy metabolism, delaying myocardial aging.

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