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The Effect of Additional Tong Xie Yao Fang on Calcitonin Gene-Related Peptide and Endothelin Secreted by Colonic Mucosa of Diarrhea-predominant of Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Type Patient

Author: LiQiong
Tutor: ChenChaoYuan
School: Fujian University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: diarrhea-predominant of irritable bowel syndrome(D-IBS) Additional Tong Xie Yao Fang Calcitonin Gene-RelatedPeptide Endothelin
CLC: R259
Type: Master's thesis
Year: 2013
Downloads: 7
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Abstract


Objective and Significance:Through detecting the changes of calcitonin cene-related peptide and endothelin quantity secreted by colonic mucosa of diarrhea-predominant of irritable bowel syndrome(D-IBS) of Liver Stagnation and Spleen Deficiency Type Patient before and after the treatment of Additional Tong Xie Yao Fang, to observe the effect of Additional Tong Xie Yao Fang on calcitonin gene-related peptide and Endothelin secreted by colonic mucosa of Diarrhea-predominant of Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Type Patient, and to study the possible modern medicine mechanism of Additional Tong Xie Yao Fang curing D-IBS Patient. It will provide a reference for clinical judgment of the D-IBS severity, prognosis and exploring new therapeutic approach.Method:l.60cases according with Liver Stagnation and Spleen Deficiency Type of D-IBS diagnostic criteria were randomly divided into2groups by visiting order according to the random number table method,30patients in each group, then were set up as traditional Chinese medicine and western medicine treatment group,and to scored before and after the treatment of treatment groups according to symptom class and quantization standard.2.30healthy subjects without any symptoms like IBS were set up as normal control group.3. To get recto-sigmoid juncture mucous membrane of Additional Tong Xie Yao Fang treatment group at prior-treatment and post-treatment and normal control group through colonoscope,applied Envision of immunohistochemistry staining method to detect calcitonin cene-related peptide and endothelin quantity.Result:1.The total effective rate of the treatment of Chinese medicine treatment group for D-IBS of Liver Stagnation and Spleen Deficiency Type Patient amounted to96.7%; The total effective rate of the treatment of western medicine group for D-IBS of Liver Stagnation and Spleen Deficiency Type Patient amounted to73.3%. the difference has statistic significance(P <0.05).2. The comparison between before and after treatment with the score of western medicine treatment group’s emotional depression was not statistically different (P>0.05); in addition to the western medicine treatment group’s emotional depression,the comparison between before and after treatment with treatment groups shows the symptom score and symptom total score were significantly reduced, the difference has statistic significance (P<0.05).3. After treatment, the score of chinese medicine treatment group’s abdominal pain or discomfort, stool frequency, alvine spasm, irritability and total symptoms was lower than that of western medicine group, and the difference has statistic significance (P<O.05).4. Before treatment,the comparison between treatment groups and normal control group shows that calcitonin cene-related peptide and endothelin quantity increased, the difference has statistic significance(P<0.05).5.The comparison between before and after treatment with treatment groups shows that calcitonin cene-related peptide and endothelin quantity decreased, the difference has statistic significance(P<0.05).6. Calcitonin cene-related peptide and endothelin quantity of the two treatment groups post-treatment were not statistically different (P>0.05), while after the treatment, calcitonin cene-related peptide and endothelin quantity, traditional Chinese medicine Treatment group changed significantly compared with western medicine, and the difference has statistic significance (P<0.05).7. There was positive correlation betwween D-IBS of Liver Stagnation and Spleen Deficiency Type Patient’s symptom integration together and CGRP or ET quantity.Conclusion:1.The CGRP and ET quantity of D-IBS of Liver Stagnation and Spleen Deficiency Type Patient’s were obviously higher than health adult.2. Decreasing CGRP and ET quantity is one of the possible mechanism of action of Additional Tong Xie Yao Fang curing D-IBS of Liver Stagnation and Spleen Deficiency Type Patient.3. The CGRP and ET quantity secreted by colonic mucosa in D-IBS of Liver Stagnation and Spleen Deficiency Type Patient maybe a reference index of reflecting pathogenetic condition.4.Using Additional Tong Xie Yao Fang to cure D-IBS of Liver Stagnation and Spleen Deficiency Type Patient was proved to have reliable therapeutic effect and not have bad effect, the clinical efficacy and decreasing CGRP and ET quantity are better than Pinaverium Bromide Tablets.

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