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Clinical Study on Treatment of Ovulatory Disfunction Due to Polycystic Ovary Syndrome with the Decoction of Bushen-cupailuan and Clomifene

Author: QiuZuoMin
Tutor: TanYong
School: Nanjing University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: the decoction of bushen-cupailuan polycystic ovary syndrome ovulatorydysfunction clinical studies
CLC: R271.9
Type: Master's thesis
Year: 2013
Downloads: 40
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Abstract


Objective:TO observe the clinical curative effect of ovulatory disfunction due to polycystic ovary syndrome (PCOS) treated by the decoction of bushen-cupailuan combined with clomiphene citrate (CC), and to explore its mechanism.Methods:53patients of ovulatory dysfunction due to PCOS met the inclusion criteria as the object of observation,were randomly divided into two groups:27patients in treatment group(the decoction of bushen-cupailuan combined with CC),a total of60cycles;26patients in the control group(only CC),a total of69cycles.To observe the effect of the diameter of the dominant follicles,the rate of the cycle of ovulation and small follicle ovulation,the rate of the luteinized unruptured follicles syndrome (LUFS) and the adiaphorous cycles,the endometrial thickness and the proportion of type A endometrium in the oviposit day,the rate of the total pregnancy,the cycle pregnancy and miscarriage between the two groups of patients after treatment.Results:(1) The average diameter of the dominant follicles of the treatment group is larger than the control group in the oviposit day.the differences were significant(P<0.05).The cycle ovulation rate of the treatment and control groups are80.0%and59.4%respectively. There were significant differences between the two groups(P<0.05).The small follicle ovulation rate of the treatment group is6.3%,lower than the control group(22.0%). There were significant differences between the two groups(P<0.05).The rate of LUFS between the treatment and control group are5.0%and10.1%respectively. There were no significant differences between the two groups(P>0.05).The rate of the adiaphorous cycles of the treatment and control groups are15.0%and30.4%respectively. There were significant differences(P<0.05).(2) There were significant differences in the thickness of endometrium in the oviposit day between the two groups (P<0.01). There were also significant differences between the two groups of the number of type A endometrium in the oviposit day, which the treatment group has35cases(72.9%) and the control group has21cases(51.2%)(P<0.05).(3) The rate of the total pregnancy and the cycle pregnancy of the treatment group(15cases of pregnancy) are55.6%and25.0%,as the control group(7cases of pregnancy) are26.9%and10.1%. There were significant differences between the two groups(P<0.05). The rate of miscarriage of the treatment group(0cases of miscarriage) and the control group(2cases of miscarriage) are0.0%and28.6%respectively, the differences were significant(P<0.05).Conclusion:Through the treatment of ovulatory disfunction due to PCOS,the decoction of bushen-cupailuan combined with CC can promote the follicular development and maturation, reduce the rate of the adiaphorous cycles and small follicle ovulation, increase of the endometrial thickness and the proportion of type A endometrium in the oviposit day,enhance the rate of ovulation,total pregnancy and cycle pregnancy, lessen the rate of miscarriage.

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CLC: > Medicine, health > Chinese Medicine > Traditional Chinese Medicine Obstetrics and Gynecology > Modern medicine, obstetrics and gynecology disease
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