Dissertation > Excellent graduate degree dissertation topics show

The Research of the Relationship between IL-17,IL-23and aGVHD after Allo-HSCT

Author: MaJun
Tutor: LiuXiMin
School: Liaoning Medical
Course: Internal Medicine
Keywords: Allo-HSCT IL-17 IL-23 aGVHD
CLC: R457.7
Type: Master's thesis
Year: 2013
Downloads: 4
Quote: 0
Read: Download Dissertation


ObjectiveIn order to research the relationship IL-17, IL-23and acute graft-versus-host disease (aGVHD) in clinical allogeneic bone marrow transplantation (allo-BMT) recipients, we conducted a prospective analysis of peripheral blood IL-17,IL-23, which may have important prognostic value as a biomarker of acuteGVHD.MethodsThe level of IL-17, IL-23in the plasma were got by Enzyme Linked Immu-nosorbent Assay (ELISA). The relative expression of IL-17mRNA and IL-23mRNA transcripts in PBMCs of allo-HSCT patients was detected by real timepolymerase chain reaction (Realtime-PCR).Results(1)The test result of IL-17, IL-23in plasma in each group: comparedwith normal control group, the concentration of IL-17, IL-23in aGVHD po-sitive group was significantly increased,the difference was statistically sign- ificant (p=0.007, p=0.005),the concentration of IL-17, IL-23in negative gro-up was no evident difference, there was no statistically significant differe-nce(p=0.67, p=0.87); Compared with aGVHD negative group, IL-17, IL-23concentration in aGVHD positive group was significantly increased, thedifference was statistically significant(p=0.008, p=0.002);(2)The test result of IL-17, IL-23concentration in plasma in aGVHDpositive group at different time points: compared with14days before the aGVHD occurrence, IL-17, IL-23concentration in the plasma in aGVH-D positive group occurred on the same day was significantly increased,t-he difference was statistically significant (p=0.046, p=0.033); comparedWi-th aGVHD occurred after7days,14days,21days, IL-17, IL-23conc-entration in the plasma in aGVHD occurred on the same day was signi-ficantly increased, the difference was statistically significant (p=0.045, p=0.021, p=0.010). Concentration of IL-17, IL-23peaked, when aGVH-D occurrence. with symptom control, gradually decline;(3)The test result of IL-17mRNA, IL-23mRNA relative expression inperipheral blood mononuclear cells: compared with control group, the relativeexpression of IL-17mRNA, IL-23mRNA in aGVHD positive group wassignificantly increased, the difference have statistical significance (p=0.042, p=0.015), and the relative expression of IL-17, IL-23mRNA in aGVHD negativepatients has no obvious change, there was no statistically significant difference(p=0.78, p=0.82). Compared with aGVHD negative patients,the relativeexpression of IL-17, IL-23in aGVHD positive group increased significantly,the difference was statistically significant (p=0.021, p=0.017).ConclusionThe level of IL-17and IL-23were all increased in the patients with aGVHDwhich may have important prognostic value as a biomarker of aGVHD.

Related Dissertations

  1. Effects of Blockade of IL-17 in Already Established Asthma of BALB/c Mice,R562.25
  2. A Stuty on the Diversification of Interleukin-17 of Asthma Mouse and the Affection of the Treament of Glucocorticoids,R562.25
  3. Asthma serum IL-17 and IgE changes and Correlation Analysis,R562.25
  4. Detection and Quantification of Th17 Cells and IL-17 in the Peripheral Blood and Tumor Tissue in Patients with Non-small Cell Lung Cancer,R734.2
  5. The Assay and Clinical Significance of TC17 Cells and Its Main Effect Cytokine IL-17 in the Peripheral Blood of NSCLC Patients,R734.2
  6. Function of Th17 Cells and Change of CD4~+CD25~+T Regulatory Cells in Children with Henoch-Schonlein Purpura in Acute,R725.5
  7. Study on the Expression Level of Toll-like Receptor-4 and Interleukin-17 in a Mouse Model of Systemic Candidiasis,R519
  8. The Dynamic Expression of Induced IL-17 and IL-23 from Mice Infected with Schistosoma Japonicum,R392
  9. Relationship between Endothelial Cell Derived Microparticles and aGVHD in Allogeneic Hematopoietic Stem Cell Transplantation,R457
  10. The Relationship between Expression of Interleukin-17 and Ventricular Arrhythmia in Rats with Chronic Heart Failure,R541.7
  11. Experimental Study of Th17 Related Factors of Animal Models Infected with Mycoplasma Suis,S858.28
  12. TNF-α, IL-23 Expression and Their Significance in Colorectal Polyps and Colorectal Cancer,R735.35
  13. Effects and Mechanism of Arsenic Trioxide on Th17/IL-17 Axis in a Mouse Model of Asthma,R562.25
  14. The Condition of Equilibrium of Th17 Cells、Treg Cells and IL-17 in the HIV or AIDS as Well as Their Influence in HAART for One Year,R512.91
  15. The Roles and Mechanisms of Methotrexate or Simvastatin on Th17/IL-17 in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis in Vitro Study,R593.22
  16. The Study on Expression and Significance of Related Cytokines of Th17/IL-17 in Severe Pneumonia Induced by Klebsiella Pneumoniae,R563.1
  17. Tim-3/Galectin-9 in murine acute graft- versus-host disease expression and significance,R55
  18. COPD Patients with Plasma IL-17, sICAM-1 Levels Changes and the Relevance of Research,R563.9
  19. The Clinical Significance of IL-17 in Gastric Cancer,R735.2
  20. The Study of IL-17promoting Proliferation of Ovarian Cancer Stem Cell in Vitro,R737.31
  21. The Th17/CD4~+FOXP3~+Treg Cells Imbalancce Expression in the Pathogenesis of Asthmatic Children,R725.6

CLC: > Medicine, health > Clinical > Therapy > Blood Therapy > Bone marrow transplant
© 2012 www.DissertationTopic.Net  Mobile