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Study for Relationship between the Polymorphism of Angiogenesis Ⅱ Type2Receptor (AT2R) Gene C3123A and Essential Hypertension (EH) and Its Related Risk Factors in Hui and Han Nationality of Ningxia Province, China

Author: WangLu
Tutor: MaPing
School: Ningxia Medical University
Course: Internal Medicine
Keywords: essential hypertension gene polymorphism angiogenesis Ⅱ type2receptor Hui nationality Han nationality
CLC: R544.1
Type: Master's thesis
Year: 2013
Downloads: 6
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Abstract


Objective To investigate the association between the polymorphism of angiogenesisⅡtype2receptor (AT2R) gene C3123A with essential hypertension (EH) and its related riskfactor in Hui and Han nationality in Ningxia Province.Methods The genomic DNA was extracted from the peripheral blood of524peoplesin Ningxia Region.Polymerase chain reaction (PCR) and restriction fragment lengthpolymorphism (RFLP) methods were used to detect the C3123A polymorphism of AT2Rgene in Hui nationality including133patients with EH and105normal controls,in Hannationality including137patients with EH and149normal people as control.The frequenciesof genotype and allele frequency distribution in Hui and Han nationality of essentialhypertension in Ningxia were studied.Result (1) Hui nationality:In male subgroup The allelic frequencies of C3123and3123A were81.5%and18.5%in EH group,while those in normal group were83.6%and16.4%,respectively,which showed no significant difference (P>0.05);In female subgroupThe distribution genotype frequencies of CC,CA,AA were32.9%,57.0%and10.1%in EHgroup,and those in normal group were36.0%,60.0%and4.0%;The allelic frequencies of Cand A were61.4%and38.6%in EH group,while66.0%and34.0%in normalgroup,respectively,all those showed no significant difference (P>0.05).(2)Han nationality：Inmale subgroup The allelic frequencies of C3123and3123A were87.3%and12.7%in EHgroup,while those in normal group were84.1%and15.9%,respectively,which showed no significant difference (P>0.05);In female subgroup The distribution genotype frequencies ofCC、CA、AA were37.9%,57.6%,4.5%in EH group,and those in normal group were47.7%,48.8%and3.5%;The allelic frequencies of C and A were66.7%and33.3%in EHgroup,while72.1%and27.9%in normal group,respectively,which showed no significantdifference (P>0.05).(3)In male and female subgroup,there was no significant difference in thegenotype frequencies of AA, AC, CC and the A/C allele frequencies between Hui and HanEH group,Hui and Han normal group (P>0.05).(4)In male subgroup:The distribution ofsystolic blood pressure,diastolic blood pressure, mean arterial pressure had no significantdifference between the CC, AA genotype groups (P>0.05);In female subgroup:Thedistribution of those blood press index also showed no significant difference among theCC,CA and AA genotype group (P>0.05).(5)In male subgroup:Han nationality,year,BUN andBMI were found as independent risk factor for EH according to binary stepwise logisticregression analysis;In female subgroup:BUN and Cr were found as independent risk factor forEH.Conclusion (1)The distribution of AT2R gene C3123A polymorphism was nosignificant difference between the Hui and Han,EH and NT group in NingXia;(2)There wasno significant association between the C3123A gene polymorphism and blood press in maleand female subgroup;(3)The C3123A polymorphism of AT2R gene was not considered to beindependent risk factor for EH in Ningxia population.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
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