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The Effect of Intraperitoneal Catheter Drainage to Ca2+ Overload in Pancreatic Acinar Cell of Rats with Severe Acute Pancreatitis

Author: LiPengWu
Tutor: GongJianPing
School: Chongqing Medical University
Course: Surgery
Keywords: catheter drainage Ca2+ interleukin minimally invasive
CLC: R657.51
Type: Master's thesis
Year: 2013
Downloads: 11
Quote: 0
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Abstract


Objective To investigate the effect of intraperitoneal catheterdrainage to Ca2+overload in pancreatic acinar cell of rats with severe acutepancreatitis by setting an intraperitoneal catheter drainage to the rats.Methods Seventy-two male Wistar rats were equally randomizedinto the sham operation group, SAP model group and catheter drainagegroup. The last two groups were induced by retrograde cholangiopancreaticduct injection of3%sodium taurocholate, and then catheter drainage groupwas induced by placing an intraperitoneal catheter drainage for drainageof ascites. The three groups of rats were put to death in the postoperative6h,12h,24h sentinel(eight mice at each time point). Take venous blood andascites to detect interleukin hormone(IL)-8, tumor necrosis factor(TNF)-ɑinflammatory cytokines thromboxane(Tx)A2and amylase(AMY),phospholipase(PL)A2activity, take pancreatic tissue to detect theconcentration of [Ca2+]iin acinar cell and make HE staining biopsy.Results At6h,12h,24h three time points,the serum IL-8, TNF-ɑ, AMY, TxA<sup>2+2, pancreatic tissue PLA2and acinar cells[Ca]iof catheterdrainage group were significantly lower comparing to the SAP group.Conclusion Drainage of the inflammatory cytokines IL-8, TNF-ɑ,etc, by setting an intraperitoneal catheter drainage to rats, can reducegeneration of TxA2、LT and activity of PLA2, reduce the injury to thepancreas, and this is maybe owing to the alleviate of calcium overload inpancreatic acinar cells.

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CLC: > Medicine, health > Surgery > Of surgery > Abdominal surgery > Pancreas > Pancreatitis
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