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Objective To investigate the changes of coagulation in children with atrial septal defect (ASD) after transcatheter closure and safety of interventional therapy.Methods (1) Nineteen consecutive patients (13females,6males, mean age6.7±4.3years) who underwent successful transcatheter closure of ASD defect with the Amplatzer ASD occluder were prospectively studied. Serum levels of prothrombin fragment1+2(F1+2), β-thromboglobulin (β-TG), tissue-type plasminogen activator (t-PA), D-dimer (D-D) were measured by enzyme linked immunosorbent assays (ELISA) before the procedure, at once, at1,30,90days following device implantation.(2) Using transthoracic echocardiography (TTE) to detect the presence of residual shunt, device malposition, and thrombus formation.Results (1) Compared with the group of pre-occlusion, the contents of serum F1+2, t-PA, D-D, raised at the end of closure procedure(P<0.05), levels were still high in first day after occlusion but there were no statistical significance(P>0.05), and gradually return to the baseline levels at30days after occlusion, β-TG levels raised at the end of closure procedure(P <0.05), returning to the baseline level at1st day after occlusion.(2) There were no residual shunt, device malposition, thrombus formation on device surface be found in following up by TTE. after occlusion.Conclusion Coagulation is activated in early and recovered soon after transcatheter closure in children with ASD, interventional therapy is safe and efficient in children with ASD. Objective To investigate the inflammatory reaction in children with atrial septal defect (ASD) after transcatheter closure and safety of interventional treatment.Methods Nineteen consecutive patients (13females,6males, mean age6.7±4.3years) who underwent successful transcatheter closure of ASD defect with the Amplatzer septal occluder were prospectively studied. Serum levels of interleukin-6(IL-6), tumor necrosis factor-a (TNF-a) were measured by ELISA just before and at once, at1,30,90days after planting the device, c-reactive protein (CRP) was measured by gold standard method before, at once, and at1day after the procedure, and compared these markers of inflammatory reaction between groups of ASD diameter≥10mm and<10mm, two types of ASD occluder, the period of procedure≥60min and<60min, males and females before and after occlusion.Results Compared with the group of pre-occlusion, the contents of serum IL-6and TNF-a raised at the end of closure procedure(P<0.05), gradually return to the baseline levels at90days after occlusion, CRP levels were not changed at any detective time point(P>0.05), There were no differences between groups of different size(≥10mm and<10mm) and corporation of ASD occluder, different times of transcatheter closure(≥60min and<60min) and gender in levels of IL-6, TNF-a and CRP(all>0.05).Conclusion Inflammatory reaction is activated in early and self-limited after transcatheter closure in children with ASD, interventional treatment in children with ASD is safe and efficient.
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