Dissertation > Excellent graduate degree dissertation topics show

Progress of EML4-ALK Fusion Gene in the Indvidual Treatment of Non-small Cell Lung Cancer

Author: SunBing
Tutor: ChenLi
School: Chongqing Medical University
Course: Surgery
Keywords: non-small cell lung cancer individualized therapy EML4-ALK fusion gene ALK inhibitors
CLC: R734.2
Type: Master's thesis
Year: 2013
Downloads: 44
Quote: 0
Read: Download Dissertation

Abstract


According to statistics, the incidence rate and mortality rate of lungcancer is the highest in the malignant tumor around the word, the incidenceis still on the rise. With the progress of science and technology, especially thedevelopment of medical molecular biology and the improvement of genetictesting technology, the pathogenesis of lung cancer has also achieved somebreakthroughs. The treatments of lung cancer had gone from "treat the samediseases with the same method " or " treat different diseases with the samemethod" into " treat different diseases with different treatments ",the newera of individualized therapy. Recently, the echinodermmicrotubule-associated protein-like4-anaplastic lymphomakinase(EML4-ALK) fusion gene has been proved to be another newmolecular target for non-small cell lung cancer(NSCLC). EML4-ALKfusion gene is most often detected in never or low smokers with lungadenocarcinoma patients and has unique pathologic features.EML4-ALKhas tumorigelicity both in vitro and in vivo. ALK kinase inhibitors showedgood efficacy in preclinical studies,more and more ALK inhibitors have entered into clinical studies.This review will systamatically introduce themolecular biology characteristics, signal transduction mechanisms, clinicalfeatures, detections, clinical researches, mechanisms of resistance andclinical prognosis in EML4-ALK NSCLC patients.

Related Dissertations

  1. Methylation of p16 Gene in Plasma and Tissues from Non-small Cell Lung Cancer Patients, Demethylation and the Biological Behavior of Lung Cancer Cell and Transcription of p16 Gene,R734.2
  2. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  3. The Effect of RNA Interference-mediated ERCC1 Gene on the Chemo-treatment Sensitivity of NSCLC in Vitro,R734.2
  4. Non-small Cell Lung Cancer Analysis of 133 Cases of CVATS Lobectomy,R734.2
  5. Clinical Observation of Pemetrexed for Treating Advanced Non-small Cell Lung Cancer,R734.2
  6. Expression of Chemokine Receptor CCR5 in Human Non-small-cell Lung Cancer,R734.2
  7. Clinical Research on Detecing of the Combined Survivin mRNA with Cytokeratin 19(ck19) mRNA in Peripheral Blood of Non-small Cell Lung Cancer,R734.2
  8. The Molecular Biology of Rh-endostatin Plus Chemotherapy as Adjuvant Treatment for Non-small Lung Cancer,R734.2
  9. Effectiveness of Erlotinib as the Sennd-line Therapy in Patients with Advanced NSCLC,R734.2
  10. Enhancing Effect of Newcastle Disease Virus in Combination with Chemotherapy for Patients with Advanced Non-small Cell Lung Cancer,R734.2
  11. Clinical Study of Endostar Combined with Pemetrexed for Advanced Non-small Cell Lung Cancer,R734.2
  12. Association of Expression of ERCC1/RRM1 with Survival and Resistance to Platinum Inpatients with Ⅰ-ⅢA NSCLC,R734.2
  13. Analysis of Efficacy of Radiotherapy and 5-FU Slow Release Particles in Treating Non-small Cell Lung Cancer,R734.2
  14. Expression and Prognostic Significance of TS and BRCAl mRNA in Non-small Cell Lung Cancer,R734.2
  15. Restructuring Agkistrodon disintegrin Adinbitor human non-small cell lung cancer cell line A549,R285.5
  16. Expression and Pathobiological Significance of Survivin, p53 and Bcl-2 Proteins in NSCLC,R734.2
  17. Association Between Polymorphisms of ERCC1 and XPD and Sensitivity to Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer,R734.2
  18. Research on Expressions and Significance of CtBP2 in Non-small Cell Lung Cancer and Its Relationship with p53,R734.2
  19. The Cox Regression Analysis of the Elderly Patients with in Advanced Non-small Cell Lung Cancer,R734.2
  20. The Chemotherapy Efficacy and Prognosis Analysis of Advanced Non Small Cell Lung Cancer,R734.2
  21. The Expression and Mechanism of Micrornas in Drug-resistant Nsclc Cell Line A549/DDP,R734.2

CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
© 2012 www.DissertationTopic.Net  Mobile