Dissertation > Excellent graduate degree dissertation topics show

Expression of MACC1Protein in Colorectal Cancer and the Correlation with Liver Metastasis

Author: ZhangLi
Tutor: XiongZhiFan
School: Huazhong University of Science and Technology
Course: Department of Gastroenterology,
Keywords: MACC1protein colorectal cancer liver metastasis Immunohistochemistry
CLC: R735.34
Type: Master's thesis
Year: 2013
Downloads: 3
Quote: 0
Read: Download Dissertation


Aimes: To investigate the expression of MACC1protein in colorectal cancer, colorectaladenoma, normal colorectal tissue, and analysis the correlation with development and livermetastasis of colorectal cancer.Methods: The expression of MACC1protein was detected by SABC immunohistochemicalmethod in colorectal cancer tissue (with26no liver metastasis and14liver metastasis tissue),colorectal adenoma, normal colorectal mucosa. we analyzed to demonstrate the correlationwith the histological grade, Dukes′stages, lymph node metastasis and liver metastasis.Results: The expression level of MACC1protein in colorectal adenoma mucosa and normalcolorectal mucosa were significantly lower than that in colorectal cancer. The expression ofMACC1protein in colorectal cancer with lymph node metastasis was significantly higherthan that with no lymph node metastasis. The expression of MACC1in colorectal cancerwith liver metastasis including synchronic hepatic metastasis and heterochronic hepaticmetastasis were significantly higher than that with no liver metastasis.Conclusions:MACC1protein plays a great role in the course of generation, developmentand liver metastasis of colorectal cancer. The high expression of MACC1protein incolorectal cancer tissue may be considered as an indicator for hepatic metastasis of colorectalcancer.

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Study of Kisspeptin/GPR54 System on the Reproductive Regulation in the Hen’s Hypothalamus-Pituitary-Ovary Axis,S831
  3. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  4. Effects of the Therapeutic Communication System Intervention on the Illness Uncertainty of Preoperative Colorectal Cancer Patients,R473.73
  5. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  6. The Effects of RIP on the Immune Function of Renewal Rats Without Colostrums,S853.7
  7. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  8. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  9. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  10. Expression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Pathological Changes of Sternocleidomastoid of Congenital Muscular Torticollis and Four Years Clinical Followed-up for Opereated Patients,R726.8
  11. Expression Characteristics and Clinical Significance of Caveolin-1 in Glioma,R739.4
  12. CK5 / 6 and EGFR as triple negative breast cancer prognostic factors analysis,R737.9
  13. Glioma resistance related gene expression and its clinical significance,R739.4
  14. Expression and Signification of Chemokine Receptors and Their Ligands in Primary Central Nervous System Lymphoma,R739.4
  15. The Expression of GPC3、 AFP、 HCG and CD34 in Hepatocellular Carcinoma,R735.7
  16. The Animal Study of Biological Active Peptide RGDS Inhibits Colorectal Cancer from Liver Metastases,R735.34
  17. The MRI Application Study of RGD-Gd Targeting Fluorescent Nanoparticle Probe in Vitro Colorectal Cancer Cells,R735.34
  18. The Effect of CDK8-siRNA on the Growth and Apoptosis of HCT116 Cells,R735.35
  19. The Expression of Neuroglobin in Retina of Diabetic Rats,R774.1
  20. Expressions of P21 and P27 Proteins in Hypopharyngeal Carcinoma and Their Clinical Significance,R739.63
  21. Clinicopathological Characteristics and Prognostic Factors in Patients with Colorectal Cancer,R735.3

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
© 2012 www.DissertationTopic.Net  Mobile