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Evaluation of Blood Supply of Primary Liver Cancer before and after Transcatheter Arterial Chemoembolization with Low Dose Whole Liver Perfusion by the Second Generation of Dual-source CT

Author: MeiXiLong
Tutor: XiaoEnHua
School: Central South University
Course: Medical Imaging and Nuclear Medicine
Keywords: Tomography X-ray computed perfusionimaging low dose TACE
CLC: R735.7
Type: Master's thesis
Year: 2012
Downloads: 17
Quote: 0
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Abstract


Objective:Explore scanning technology and radiation dose of low-dose whole liver perfusion with the second-generation dual-source CT; observed blood supply of primary liver cancer before and after TACE operation with low-dose whole liver perfusion scans by second-generation of dual-source CT.Materials and Methods:21cases of patients with Primary liver cancer (male19cases, female2cases, mean age,47years, range,29-79years) treated with TACE were collected. Of them,4patients with normal preoperative AFP were confirmed with needle biopsy; other17patients were comprehensively diagnosed by AFP, CT, MRI, including1patient whose preoperative AFP was1000was furtherly confirmed after Ⅱ-phase resection.20patients had a history of hepatitis.In advance routine liver perfusion scan with water mode and record the radiation dose by second-generation of dual-source CT. All subjects were randomly divided into Groups A, B.In A group(10cases), kV was100kV;mAs was80mAs. In B group (11cases), kV was80kV; mAs was110mAs. The other conditions were the same in both groups. All patients were routinely performed liver III phase enhancement scan and then3hours later low dose CT perfusion scan in the3days to1weeks before TACE and30to35days after TACE, respectively.low-dose perfusion scan radiation dose of A and B respectively compared with scanning radiation dose of the model and scan dose of the liver conventional plain and enhancedResult:The whole liver low dose CT perfusion scan was successful, obtaining the satisfactory whole liver perfusion maps and thin-section volumetric image data in21patients with Primary liver cancer in A and B groups before and after TACE. The changes of low dose CT perfusion parameters(BF, BV, ALP, HPI) before and after TACE had statistical significance using paired sample t test(P<0.05). There were significant lower radiation doses of patients in A and B groups than conventional perfusion of the same range body model preset by the machine by a single sample t test(P<0.05), there were significantly higher radiation doses of patients in A group than at the time of normal hepatic enhancement scan by a single sample t test(P<0.05),but not significantly higher in B group(P>0.05).The satisfactory hepatic arterial and Portal vein CTA images were obtained by processing after the thin-section volumetric images were loaden in the statio.Conclusion1. The satisfied whole liver low-dose perfusion maps could be got by second-generation dual-source CT pitch reciprocating scan mode by lowering20%kV value and about10%mAs value.2. The blood supply of primary liver cancer tumor could be observed with the whole liver low-dose perfusion by Second-generation dual-source CT.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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