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Background Acute Coronary Syndrome (Acute coronary syndrome, ACS) is a serious cardiovascular disease, including unstable angina (Unstable angina pectoris, UA), acute non-ST-segment elevation myocardial infarction (Non-ST elevated myocardial infarction, NSTMI) and ST-segment elevation myocardial infarction (ST elevated myocardial infarction, STMI), and sudden death. Coronary plaque instability, rupture, complicated by thrombosis, caused a the acute coronary luminal obstruction or coronary artery stenosis dramatic increase in its main mechanism. Inflammatory reaction occurred in unstable plaque evolution, plays a vital role in the process of rupture and thrombosis, proinflammatory cytokines and anti-inflammatory cytokines to participate in the pathophysiological process. Recent studies show that, in patients with ACS serum soluble E-select prime (soluble E-selectin, SES) level than the normal control group have significantly increased, the level of interleukin Su -10 (Interleukin-10, IL-10) also have significant change, suggesting that inflammatory factors The SES and anti-inflammatory cytokine IL-10 may be related to the occurrence and development of coronary heart disease and plaque instability, and prognosis of coronary heart disease may have predictive value. Objective: To observe the different types of coronary heart disease in patients with SES, IL-10, hs-CRP levels of analysis of the relationship between SES, IL-10 and hs-CRP and coronary lesion extent of serum the SES, IL-10 detection for the evaluation of plaque block stability and the value of the degree of coronary artery lesions. Materials and Methods clinically suspected underwent coronary angiography, a total of 94 cases of coronary heart disease hospitalization. Coronary angiography is completely normal, and except for coronary heart disease as a control group, a total of 32 cases; coronary angiography showed a clear lesion, and belongs to SAP in 23 cases; ACS, 39 patients (including unstable angina in 19 cases, acute myocardial infarction in 20 cases). By ELISA for quantitative detection in peripheral blood SES, IL-10, hs-CRP by immune transmission turbidimetric method. All coronary angiography showed stenosis ≥ 25% lesion imaging analysis. Results (1) the level of serum SES ACS group (2.11 ± 0.13ng/ml) was significantly higher than the SAP group and the control group (1.37 ± 0.16,1.42 ± 0.14 ng / ml) (P lt; 0.01), and SAP group and control group no significant difference (P gt; 0.05); serum IL-10 levels in ACS group (402.87 ± 19.21pg/ml) was significantly higher than that in the SAP group and the control group (330.52 ± 25.01,300.47 ± 21.20 pg / ml) ( P lt; 0.05, P lt; 0.01), and between the SAP and control groups no significant difference (P gt; 0.05); serum hs-CRP level in ACS group (773.33 ± 50.49ug/dl) was significantly higher than the SAP group between SAP and control groups and the control group (399.96 ± 65.75,231.75 ± 55.74 ug / dl) (all P lt; 0.01), no significant difference (P gt; 0.05); (2) the ACS in serum SES level hs-CRP levels was positive related (P lt; 0.05, r = 0.260) of IL-10 and hs-CRP levels no related resistance (P gt; 0.05, r = 0.098); (3) the ACS group and SAP group serum SES IL-10, hs-CRP levels and the number of diseased vessels were not correlated (r = 0.093, -0.026,0.056, both P gt; 0.05) with Gensini scores were not correlated (r = 0.043, -0.077 0.051, all P gt; 0.05). Conclusion (1) ACS serum SES to the level of IL-10 significantly increased, suggesting that the SES serum IL-10 increased may be unstable plaque, SES, IL-10 can be used as the detection of unstable plaque, and crown a valuable indicator of heart disease risk stratification. (2) SES, no significant correlation between the level of IL-10 levels and coronary lesion stenosis.
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