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Ginger ethanol extract of alcoholic liver injury in mice and related antioxidant activity of

Author: XuDiBo
Tutor: PengJing
School: Yangzhou University
Course: Nutrition and Food Hygiene
Keywords: Ginger Gingerol Alcoholic liver injury Antioxidant activity
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 156
Quote: 1
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Abstract


Ginger for the fresh rhizome of the ginger plant (Zingiber officinale Rosc). Modern research has found a variety of effects of the the ginger active ingredients have antioxidant and free radical scavenging, lowering cholesterol, lowering blood pressure, protective and choleretic. The free radicals generated in the process of alcohol metabolism, is one of the important factors that lead to alcoholic liver injury induced lipid peroxidation. Therefore, the ginger protective and choleretic, free radical scavenging effect it has huge development potential in the prevention and treatment of alcoholic liver injury. This topic extracts of ginger ethanol early intervention alcoholic liver injury research and press the polarity of the separation and determination of antioxidant activity of the extract, filter out the optimal active site. The beginning of a ginger ethanol extracts prepared and polar fractions to separation by ethanol extraction, and concentrated under reduced pressure and freeze-dried to obtain the beginning of ginger ethanol extract. AB-8 macroporous resin according to the polarity of ginger extract (First extract) separation to get the water phase, 25% ethanol, 50% ethanol, 75% ethanol, 95% ethanol and 5 polar fractions . The 2 ginger ethanol early mention the material and separated parts ginger capsaicin determination of vanillin as the standard, the standard curve, using vanillin standard curves beginning of ginger ethanol extract gingerol content of 6.4%, each separated parts of gingerol pigment content: water phase containing 1.3%, containing 11.5% of 25% ethanol, 50% ethanol containing 34.7%, containing 32.3% of 75% ethanol, 95% ethanol containing 28.5%. 3 ginger ethanol early to mention the matter and separated parts of antioxidant activity assay produced liver homogenate lipid peroxidation model induced generation of MDA determination ginger beginning of extracts and the separated parts of the product rate of the liver homogenate generation MDA inhibition. 50% ethanol inhibition of MDA IC50 of 0.3mg/mL, the best 75% ethanol phase was 0.3mg/mL both better than vitamin E. SOD-like activity: 50% ethanol (1.0mg/mL) SOD activity of 19.59 U / mL, 75% ethanol to 19.05 U / mL. The two-phase activity in the corresponding concentration was no significant difference (p gt; 0.05). 4 ginger ethanol extract of early intervention murine alcoholic liver injury and normal control group, model group, low, medium and high dose groups. In addition to the normal control group, each group gavage 10mL/kg and 50% (v / v) concentration of white wine, 1 / d, alcoholic liver injury, low, medium, and high dose group were given 120mg/kg 240mg / kg, 480mg/kg ginger alcohol extract as intervention, normal control group was given the same amount of distilled water as a control intragastric administration for 30 days after the determination of serum glutamic acid aminotransferase enzyme (ALT), aspartate aminotransferase enzyme (AST) and liver malondialdehyde (MDA), superoxide dismutase (SOD). Model group, ALT, AST, the content of MDA increased and SOD decreased, compared with the normal control group difference was significant (p lt; 0.05 or p lt; 0.01), the intervention group compared with the model group, each index improved in different degrees, The effect of high-dose group was more significant (p lt; 0.01).

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