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Research on Novel Nitric Oxide-releasing Donors

Author: YuYanMei
Tutor: GuJinLou
School: East China University of Science and Technology
Course: Materials Science and Engineering
Keywords: Mesoporous materials Nitric oxide donors Nanogels
CLC: TB34
Type: Master's thesis
Year: 2012
Downloads: 95
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Abstract


In this thesis, a special attention was paid to prepare nitric oxide-releasing mesoporous silica nanoparticles(MSNs) and nanogels. Firstly, cubic MCM-48 nanoparticles with uniform size and highly-ordered structure were synthesized, then we got two kinds of nitric oxide donors by grafting nitric oxide precursors. We also studied the NO-releasing properties of the nitric oxide donors in physiological conditions. Besides, we synthesized chitosan nanogel with gold nanoparticles in the core and investigated its application for NO-releasing in situ in plasma.We first synthesized nitric oxide donor N-diazeniumdiolate with MSNs as scaffold which remained the spherical morphology and ordered structure of MSNs. It may release nitric oxide for more than 48 hours, the amount of which equaled to 0.148μmol/mg. By the same method, we prepared MSNs/RSNOs which was another nitric oxide donor. The MSNs/RSNOs can be decomposed to release nitric oxide by three initiators which are copper(Ⅱ), ascorbate and light. The results showed that the speed and amount of NO-releasing were proportional to the concentration and intensity of the initiators. What’s more, the photoinitiated NO-release of MSNs-RSNOs is controllable. Besides, we not only remained the property of gold nanoparticles but also reduced the physiological toxicity by coating the gold in the core of chitosan nanospheres. When in contact with plasma, the RSNOs in plasma can release nitric oxide in situ by the catalysis of the gold@chitosan nanogel. The more of the concentration of the gold nanoparticles, the more of amount of nitric oxide-releasing.

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