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Objective : To observe the low level of controlled hypotension (MAP 45 ~ 50mmhg) cognitive function after spinal surgery patients , and provide a reference for clinical application . Methods: A healthy adult patients 60 cases of internal fixation surgery under general anesthesia for elective lumbar decompression level the ASAI, - II , age 18-59 years old , weighing 45- 85kg . Randomly divided into 3 groups (n = 20), normal blood pressure group (C ) , the usual level of controlled hypotension group (D1 group :55- 65mmHg ) , the lower the level of controlled hypotension group ( D2 group : 45 ~ 50mmHg ). Group processing , D1 , and D2 group C group was not in surgery after the start of continuous infusion of sodium nitroprusside ( SNP ) 0.5-6μg/kg min , mean arterial pressure (MAP) fell within 30min to target blood pressure (D1 group 55-65mmHg, D2 group of 45 ~ 50mmHg). Surgery to adjust the the SNP dosage to maintain this level of hypotension , disable SNP natural complex pressure to close the incision . (T2), 10 min (T1), in controlled hypotension ago , to reach target blood pressure reached target blood pressure after 60 min (T3), complex pressure (T4), the end of surgery (T5) point-in-time acquisition neck bulbar vein blood determination of the internal jugular venous bulb oxygen saturation value (SjvO2) , neuron-specific enolase (NSE) and S100β protein content . Applications Mini-Mental State Examination (MMSE) assessment of preoperative ( basal state ) after one day , two days , three days , five days of cognitive functional status . Results: 1 compared with group C , D1 group and D2 patients SjvO2 value , NSE and S100β protein content was no significant change (P gt; 0.05). 2 compared with baseline values ??, three groups of patients after one day , two days , three days , five days MMSE score difference was not statistically significant ( P gt ; 0.05 ) ; among the three groups the MMES score difference was not statistically significant (P gt ; 0.05 ) , none of the three groups of patients postoperative cognitive dysfunction . Conclusion: The lower the level of induced hypotension (MAP 45 ~ 50mmHg) line of spinal surgery postoperative cognitive function of healthy patients had no significant effect .
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