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Observing and Analyzing the Sample Diastolic Hypertension Sicker in the Treatment of the Drugs Which United the Lacidipine with the Benazepril.

Author: LuoWeiXiong
Tutor: LiZiCheng
School: Jinan University
Course: Cardiovascular
Keywords: Lacidipine Benazepril Isolated diastolic hypertension Hyperlipidemia Young and middle-aged
CLC: R544.1
Type: Master's thesis
Year: 2009
Downloads: 29
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Abstract

Objective: To observe the of Chala Xi horizon joint benazepril isolated diastolic hypertension and mild hyperlipidemia young and middle-aged faculty of efficacy. Methods: South China Agricultural University faculty examination in mid-December 2007, 46 patients with isolated diastolic hypertension (IDH) and patients with mild hypercholesterolemia in young and middle-aged faculty, the average age of 45 ± 10 years old, and the exclusion of patients with secondary hypertension Lacidipine missionary scientific behavior lifestyle, combined with benazepril treatment. Week follow-up review of the signs of the blood pressure, heart rate, timing (8 weeks, 6 months, 12 months) review the biochemical and blood lipids. Adjust the dose based on the patient's physical examination and feel the adverse reactions observed drug antihypertensive and lipid-lowering effect and the impact of drugs on the heart rate, urinalysis, blood biochemistry and adverse reactions, the time of year. Results: (1) lacidipine joint shell under constant use of enalapril effectively reduces the IDH, the effective rate of 100%, with an average diastolic blood pressure by the DBP: 93.35 disabilities 2.22mmhg fell to a year after the DBP: 74.43 Guests 2.84 mmhg. before and after treatment was statistically significant (p lt; 0.01). Two drugs at the same time reduced to half the amount still effective antihypertensive effect (100%), half of the observation period using antihypertensive effect a smooth and long-term clinical observation found no significant adverse reactions. (2) the constant use lacidipine, average heart rate rose to 74.38 ± 4.27bpm than before mild increase in heart rate, a statistically significant difference (p lt; 0.05) before and after the clinical observation of the patient and by the beginning of 71.57 ± 3.04bpm no obvious discomfort. Reducing the use lacidipine heart rate average for the 71.57 ± 3.04bpm 71.82 ± 3.25bpm before use with no significant difference (p gt; 0.05). (3) high blood pressure before and after combination therapy in patients with blood, urine, and liver. Renal biochemical examination was no significant difference (P> 0.05). (4) when in constant use, lacidipine total of three cases of adverse reactions (6.52%), benazepril cases of suspected adverse reactions (2.17%), can be tolerated. Significantly reduced in the reduction of the use of adverse reactions. (5) lifestyle changes in patients with the prevention and treatment of high blood cholesterol (hypercholesterolemia) may have a role, with an average blood lipids dropped to a year after the beginning of 5.84 ± 0.22mmol / 1 Average lipids 5.72 ± 0.19mmol / 1. The lipids change before and after the intervention was statistically significant (p lt; 0.05). Conclusion: 1 gt; the lacidipine combined with benazepril daily dose can significantly lower blood pressure (systolic and diastolic) (P lt; 0.05). Half the amount of use of reducing simple diastolic blood pressure effect is still evident (P lt; 0.05). 2 gt; constant lacidipine a mild reflex cardiac acceleration performance, but clinical use in patients with no complaints obvious discomfort. Halve the amount of use, heart rate Reply medication before basic level. 3 gt; prolonged use of the two drugs adverse reactions are mild, the patient can be basically tolerated. 4 gt; joint use of lacidipine with benazepril IDH patients no significant effect on blood, urine, liver and kidney function, worthy of clinical use in patients with simple diastolic hypertension (IDH). 5 gt; lifestyle changes in the prevention and treatment of patients with IDH and high cholesterol (hypercholesterolemia) may have a certain role, whether there has yet to be examined because a good buck factors, clinical attention should be paid to the importance of non-drug treatment sex.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
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