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KONG Yinghong,CHENG Xingbo.Department of Endocrinology,the First Affiliated Hospital of Soochow University,Suzhou 215006,CHINAObjective To explore the change and clinical significance of serum vaspin levels in patients with type 2 diabetes mellitus(T2DM) and T2DM patients with microangiopathy. Methods 80 patients with T2DM were divided into two subgroups according to UAER≥and <20μg/min:diabetes group(SDM , 40cases) and diabetic nephropathy group(DN,40cases).And 30 subjects with normal glucose tolerance were selected as controls(NC,30cases).The level of fasting serum vaspin was measured by enzyme-linked immunosorbent assay.Results The serum vaspin levels of the three groups turned to be DN group <NC group <SDM group.Correlation analysis showed that vaspin correlated with sex,BMI,FIns,HOMA-IR positively.Vaspin was negatively correlated with duration and UAER.In a multiple stepwise linear regression analysis,sex,BMI and FIns were independent determinants for serum vaspin concentrations.Conclusion Serum vaspin may contribute partly to the pathogenesis of obesity,insulin resistance,T2DM and microangiopathy of diabetes.
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