Dissertation > Excellent graduate degree dissertation topics show

Synthesis and Biological Activities of 1,2,3-Thiadiazole-Containing Heterocyclic Derivatives

Author: ZhangDanFeng
Tutor: PengYanQing
School: East China University of Science and Technology
Course: Plant Protection
Keywords: Plant elicitor 1,2,3-Thiadiazole Heterocycles Biological activities
CLC: O626.25
Type: Master's thesis
Year: 2012
Downloads: 65
Quote: 0
Read: Download Dissertation

Abstract


Plant disease caused by fungi is a serious threat to agriculture and horticulture all over the world. Traditional fungicides play a critical role in the plant protection by killing or controlling target fungi directly, sometimes caused adverse effects to the environment, and often led to the fungicide resistance too. Hence, from both academic and practical points of view, it is very important to develop new environment-benign fungicides for plant protection. Plant activators (also called elicitors) themselves and their metabolites had no distinct direct fungicidal activity, they induce the immunological system of the plant to produce a broad spectrum of systemic acquired resistance by altering the physiological status of the host plants and, therefore, are among the most attractive directions in modern green pesticide development. However, only a limited number of commercial elicitors are available; the most successful elicitor commercialized is acibenzolar-S-methyl (BTH). Tiadinil (TDL) is another successful elicitor commercialized for disease control.1,2,3-Thiadiazole has been found as the crucial moiety in these elicitors. In this dissertation, series of 1,2,3-thiadiazole derivatives (62 compounds) are designed and synthesized with the active group 1,2,3-thiadiazole as a parent, namely:(1) A series of compounds in which 1,2,3-thiadiazole ring were connected with N-substituted amino-1,3,4-thiadiazole scaffolds; (2) A series of compounds in which 1,2,3-thiadiazole ring were connected with 1,2,4-triazole-3-thiodone scaffolds; (3) A series of hydrazone and hydrazide derivatives containing 1,2,3-thiadiazole moiety. Their potential systemic acquired resistance as elicitors was also evaluated. Bioassay results indicated that the N-substituted amino-1,3,4-thiadiazole derivatives had no notable in vitro fungicidal activities, while the compound A08 showed certain induction activity. 1,2,4-Triazole-3-thiodone derivatives had no obvious in vitro fungicidal activities, but several compounds showed certain induction activities for plants against Phytophthora infestans and Corynespora cassiicola; for example, compound B01 had a satisfactory induction activity against Phytophthora infestans. Among twenty evaluated 1,2,3-thiadiazole acylhydrazone derivatives, no remarkable in vitro fungicidal activities was observed; however, several compounds (e.g. D07 and D09) were found to be satisfactory in plant activating. 1,2,3-Thiadiazole hydrazides had no in vitro and in vivo fungicidal activities.

Related Dissertations

  1. Study on the Synthesis and Biological Activity of D-Glucosamine Derivatives,O629.1
  2. Synthesis and Antibacterial Activities of 2/3-Alkylthio-5-o-Hydroxyphenyl Azoles Compounds,O626.2
  3. Synthesis and Properties Study of 1,3,4-oxadiazole and Thiadiazole-2-thiol Derivatives and Their Cyclometaled Platinum Complexes,O626.2
  4. Synthesis , Characterization of New 2, 5-disubstituted-1, 3, 4 - Thiadiazoles and Research Synthetic Method of Diaryl Ethers,O621.3
  5. Study of Tribological Characteristics and Action Mechanism of New Thiadiazole Derivatives and Triazine Derivatives,TE666
  6. Synthesis, Characterization and Biological Activities of Some Novel Oxadiazoles and Imidazo-thiadiazole Derivatives Containing Benzoxazolinon/Benzothiazolinon Moiety,TQ460.1
  7. Synthsis and Properties of Azobenzene Polymer Containing 1,3,4-oxadiazole or 1,3,4-thiadiazole Unit,O633.5
  8. Synthesis, Character of Sulfur Ether Derivations Containing 1,3,4-oxadiazole and 1,3,4-thiadiazole,TQ460.1
  9. Microwave-assisted Synthesis and Bioactivity of Novel Substituted Bisoxadiazole and Bistriazole Derivatives Containing Pyridine Rings,O621.3
  10. Synthesis and Study of Some Multi-function Group Compounds with 1,2,3-triazloe and Thiadiazole (or Thiazolidine, Pyridine),O626.2
  11. Synthesis and Study of 4-Thiazolidinones Bearing 1,3,4-Thiadiazole Ring,TQ252.5
  12. Michael Addition Reactions of 3, 4-dihydropyrimidinones and the Synthesis of 2’-(5’-aryloxymethylene-1, 3, 4-thiadiazoles-2’-amino)-arylmethyl-2-naphthols,O626.2
  13. Demethylated cantharidin radical and thiazole derivatives of transition metal complexes Synthesis , Crystal Structure and Interaction with DNA research,O621.25
  14. Spectroelectrochemical and Electroanalytical Study of Fisetin and Luteolin,O657.1
  15. Constructed based on hydrogen bonding nitrogen and sulfur compounds studied,O641.4
  16. Synthesis and Bioactive Properties Study on 1,3,4-thiadiazole Containing Hydrazones,TQ463
  17. 2 - amino -5 - aryloxymethylene- methyl-1 ,3,4 - thiadiazole Derivatives Research,TQ252
  18. Thiadiazole -containing aromatic acyl ureas and amides Synthesis and Biological Activity,TQ450.1
  19. Effect of Center Unit on the Properties of Bent-Core Liquid Crystals,O753.2
  20. Novel ferrocenyl of 1,3,4 - thiadiazole compound synthesis and biological activity test,O627.81
  21. Study of Self-Assembly Chemistry and Synthesis Based on New Type of Conjugated Fulvene Ligands and Bent Ligands Bridged by N-containing Five-membered Heterocyclic Rings,O641.4

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds > Containing five pairs or more different atoms of heterocyclic > Between sulfur and nitrogen -mao ( thiazole )
© 2012 www.DissertationTopic.Net  Mobile