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The Expression of IL-10, TNF-α in Prostate Hyperplasia and Prostate Cancer Tissue and Its Significance

Author: SunGuoHua
Tutor: XiaYuJun
School: Qingdao University
Course: Human Anatomy,Histology and Embryology
Keywords: IL-10 TNF-α Prostate hyperplasia Prostate cancer
CLC: R737.25
Type: Master's thesis
Year: 2011
Downloads: 29
Quote: 0
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Abstract


Objective Through the study of different expression of the inflammatory cell factors IL-10, TNF-αin prostate hyperplasia and prostate cancer tissues, to understand different properties of prostate disease cell biology and immunological characteristics, and to provide the basement for more specifically formulated for clinical disease screening and breakthrough the treatment methods.Methods1. Specimen collection: 20 cases with surgical treatment of prostate hyperplasia and prostate cancer were used respectively, all specimens were not special treatment before, both by pathological examination confirmed the tentative preoperative diagnosis. In another 1 abnormal death middle-aged men with no history of prostate disease diagnosis and treatment was used as the normal prostate control.2. Test methods:Immunohistochemical staining method use to observe the expression of IL-10, TNF-αin the cells of specimens tissues, and the image analysis technique was used to compare the light absorption density differences of each specimens.Results1. IL-10 in three groups specimen tissue cells were expressed, but with prostate hyperplasia express the strongest, prostate cancer is the second smallest, and normal controls most weak, using the Sample PCI image analysis system for light absorption density value measurement, IL-10 in the above three kinds of organization of the expressions were 0.3121±0.0936、0.2958±0.0329、0.0816±0.0732. TNF-αin three groups specimen tissue cells were expressed as to prostate hyperplasia express the strongest, prostate cancer is the second smallest, and normal controls most weak, using the Sample PCI image analysis system for light absorption density value measurement, TNF-a in the above three kinds of organization of the expressions were0.4021±0.0652、03259±0.0487、0.1016±0.0825.2. Choose the variance analysis Q inspection analysis, IL-10, TNF-αin three groups of specimen expression differences have statistical significance.Conclusion1. There is higher expression of IL-10, TNF -αin the hyperplasia prostate tissue;2. The higher expression TNF-αin the hyperplasia prostate tissue, maybe involved in prostate hyperplasia, organization structure damage, and cause inflammation; and the higher expression of the IL-10 in the prostate hyperplasia, may be secondary to the inflammatory response, and relevant in clinical symptoms.3. IL-10, TNF-αin prostate cancer tissue cells were expressed;4. The expressions of IL-10, TNF-αin prostate cancer tissue cells maybe involved in inflammatory response cause by rapid growth of cancer tissue.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Male genitalia tumors > Prostate cancer
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