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Measurement and Applicalication of High Scattering Matters Optical Parameters Based on Multi-Optical Path Method

Author: LiJingYao
Tutor: LiGang
School: Tianjin University
Course: Biomedical Engineering
Keywords: Multi optical path length measurement High scattering material Optical parameters Monte Carlo simulation PLS
CLC: R318.0
Type: Master's thesis
Year: 2009
Downloads: 38
Quote: 1
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Abstract


I.e. the so-called high scattering material has a relatively high scattering coefficient. Quantitative analysis of highly scattering material is divided into two parts. The first is the measurement of optical parameters of the substance itself, the material of the optical parameters of one of the fundamental properties of matter, such matter scattering coefficient, absorption coefficient, the anisotropy factor, is also an important basis for analyzing composition of a substance, especially in biological tissue optics parameter measurement is biophotonics research in the field of critical infrastructure in the field of medical diagnosis and treatment of a wide range of applications. Each component substance has a specific optical characteristics, the spectral analysis provides a quantitative basis, followed by the substances in its composition optical parameters measured spectral information carried by the substance to distinguish between different concentrations of the same material, and measuring Their content. In this paper, the two aspects of quantitative analysis combined with multi-optical path length measurement method for the optical properties of highly scattering materials research, this project has been completed the main work includes: 1) In order to improve the high scattering substance Monte Carlo simulation algorithm for computing speed In Wang et al provide multi-organizational model for the study MCML algorithm based on the improvement, respectively, for general photoelectric sensors and fiber optic sensor as the acceptance device, two different models proposed modification method, as well as by increasing constraints the approximation process, greatly improve the Monte Carlo simulation speed. 2) build their own multi-pathlength experimental platform, through its various agencies to achieve micron displacement measurement of the optical path length, as well as optical properties of highly scattering materials research, through the analysis of a single wavelength absorption coefficient derived substances reduced scattering coefficient, and through the Monte Carlo model was validated. 3) Partial least squares (PLS) method, the highly scattering substance concentration measurement study using India ink intralipid solution and the preparation of different kinds of solution concentrations of 21, using a single optical path length of the optical path length and more than the method of experiment sample measurement optical path length of single and multi-pathlength experimental data obtained were analyzed, the analysis results show that the optical path length method of multi-concentration measurement accuracy is much higher than a single optical path length method, especially for India ink, and more concentration measurement accuracy of the optical path length than a single concentration measurement optical path length of an order of magnitude higher accuracy. 4) blood component measurement technology in recent years has been the focus of biomedical research in the field. The current application is for testing are blood components in serum, plasma or analog samples, and less whole blood as a sample spectral measurements. Optical path length through a multi-method of whole blood in the visible - near infrared spectral measurements, replacing the conventional use of the recorder and blood biochemical analyzer, etc., to achieve a simple, low-cost, rapid detection of blood components and for the dynamic spectrum Non-invasive measurement of blood components to provide the basis.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues
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