Dissertation > Excellent graduate degree dissertation topics show

Effects of Uighur Medicine Ethanol Extract Ocimum Basilicum L on Cyclooxygenase Enzyme Activity

Author: JiangGuoHua
Tutor: YiBaDaiTi·TuHuTi
School: Xinjiang Medical University
Course: Pharmacology
Keywords: Basil Antithrombotic Cyclooxygenase Gastric mucosal injury
CLC: R29
Type: Master's thesis
Year: 2009
Downloads: 41
Quote: 0
Read: Download Dissertation

Abstract


Objective: ① observed Uygur medicine basil alcohol extract in vitro and in vivo cyclooxygenase -1 (COX-1) and cyclooxygenase -2 (COX-2) activity , and to explore the basil with epoxy the dismutase activity relationship to provide a theoretical basis , in order to further explore the mechanisms dimensional antithrombotic drugs basil . ( 2 ) by exploring the dimensional drug adverse reactions of the oral administration of basil , to provide a theoretical basis for the clinical Prescription drug selection . Method : ① vitro : cultured human umbilical vein endothelial cells (ECV304 cell line) and mouse peritoneal macrophages (raw246.7 cell lines ) , determined by MTT cell growth cycle and concentration ; take advantage of the cytotoxicity test basil alcohol extract of dose screening; ECV304 cells were measured by ELISA 6 - keto - prostaglandin F1α ( 6 - keto -PGF1α ) , bacterial lipopolysaccharide (LPS) -induced raw246.7 cells to produce prostaglandin E2 (PGE2) content . ② vivo experiments : with anhydrous ethanol gavage rat gastric ulcer model , observe the rat gastric mucosa , calculate the ulcer index , and the determination of the content of the gastric mucosa 6-keto-PGF1α and PGE2 . Results: ① basil alcohol extracts in vitro inhibition of COX-1 and COX-2 have different degrees of 6 - keto -PGF1α of PGE2 was significantly decreased ( P lt ; 0 , 01) , the same as in the dose , basil alcohol extract on COX-2 inhibition rate than COX-1 (P lt; 0.05). ② basil healthy rat gastric mucosa damage can reduce the ethanol - induced gastric mucosa injury , and make the content of 6-keto-PGF1α increased ( P lt ; 0.05) and no significant inhibition of PGE2 . Conclusion : ① The experiments confirmed basil alcohol extract on COX-1 and COX-2 inhibitory effect , Mechanism of antithrombotic part with likely due to inhibition of cyclooxygenase -mediated 's . ② basil of normal gastric mucosa damage can reduce the area of ethanol - induced gastric ulcer , with better protective effect on the gastric mucosa , can be widely used set of square .

Related Dissertations

  1. The Correlation between COX-2 and Ang-2 Expression in Human Gratric Cancer and Its Role in Lymphangiogenesis,R735.2
  2. Expression Influnce of Cox-2, Hmlh1, Hmsh2,bcl-2,caspase-3 in Colon Cancer lovo Cell Lines Be Treated with NSAIDs and the Mechanisms of the Anti-neoplastic Effect of NSAIDs,R735.3
  3. Dan Long Capsule treatment of ischemic stroke Pharmacodynamics,R285.5
  4. HDL Induces COX-2 Expression and PGI2 Production Through SR-B1 Mediated PI3K-Akt-eNOS Pathway in Endothelial Cells,R363
  5. Inhibition of Gastric Cancer Cells Invasion and Metastasis by Zileuton in Viro,R735.2
  6. The Clinic Curative Effect Observation of Qi Zhu Prescription Treating to PLGC and Experimental Study of the Anti-tumor Mechanism of AstragalosideIV and β-elemene,R273
  7. Yiqi-huoxue Formula Which Can Effect SOD and MDA of the Patients That Suffering Gastric Mucosa Damage Induced by NSAIDs,R285.5
  8. The Effect of the Expression of Angiotensin Ⅱ on Extracellular Matrix Metalloproteinase Inducer in Macrophages is Mediated via the AT1/COX-2/PGE2 Pathway,R543
  9. A Clinical Study about the Values of Phospholipase A2 and Cyclooxygenase-2 in Premature Delivery,R714.2
  10. The Effect of Nimesulide and Oxaliplatin on Human Lung Cancer Xenograft in Nude Mice and the Research of the Reason,R734.2
  11. The Experimental Study on the Effect and Apoptotic Mechanism of Xibofen-PDT with ASA in Eca-109 Cell in Vitro,R735.1
  12. The Significance and Relevance between the Expressions of Hypoxia-inducible Factor-1α (HIF-1α) and Cylooxygenase-2 (COX-2) in Lumbar Disc Herniation,R681.53
  13. EA Stomach Meridian related signaling molecules on gastric mucosal injury in rat serum protein expression,R245.0
  14. Sinomenine Inhibits Proliferation and Induces Apoptosis of the S180 Ascites Lump Cell to Perish Weakly and to Affect ERK-Bc1-2 Signal Transduction Circuit’s Related Mechanism,R285.5
  15. Sinomenine Induces s180 Ascites Tumor Cells Apoptosis and Related Mechanism,R285.5
  16. PE anxiolytic effects research,R96
  17. Molecular Mechanism of Paradoxical Stimulation of Cyclooxygenase-2 Expression by Glucocorticoid in Human Amnion Fibroblasts,Q78
  18. The Empirical Study Concerning the Inhibition Effect of Fructus Amomi Rotundus Combined with 5-FU on Subcutaneous Transplantation Tumor of Human Gastric Cancer Cell in Nude Mice Model,R735.2
  19. The Effects of Selected Cyclooxygenase-2 Inhibition or Dual Cyclooxygenase-2/5-lipoxygenase Inhibition on the Proliferation of Esophageal Squamous Cell Carcinoma Cells,R735.1
  20. The Effect of Non-selective Cyclooxygenase Inhibitor Versus Selective Cyclooxygenase-2 Inhibitor in Multimodal Pain Management in Patients Undergoing Total Knee Arthroplasty,R687.4

CLC: > Medicine, health > Chinese Medicine > Chinese Minority Medicine
© 2012 www.DissertationTopic.Net  Mobile