Dissertation > Excellent graduate degree dissertation topics show

Live alone the study of parasitic soup rabbit lumbar disc herniation model in vivo tumor necrosis factor in rats

Author: LiZhouJin
Tutor: WuGuanBao
School: Hunan University of Traditional Chinese Medicine
Course: TCM orthopedics and traumatology
Keywords: Decoction of Pubescent Angelica Root and Mistletoe LDH TNF-α
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 2
Quote: 0
Read: Download Dissertation

Abstract


Objeetive:To evaluate Decoction of Pubescent Angelica Root and Mistletoe’s effect on TNF-αof the patients suffering from LDH, by observing variation in content of TNF-αof LDH’spilot model which were drenched with Decoction of Pubescent Angelica Root and Mistletoe. And then definite that if the Decoction of Pubescent Angelica Root and Mistletoe have adjustive function on TNF-a or not,and take further research into molecular biological mechanisms of the treatment effect on LDH. To confirm the therapeutic action on LDH by compare with physiological saline,and compared the curative effect to Voltaren belonged to NSAID.Method:seventy five rabbits, grouped into five groups(the black group, the false Surgery Models group,the model black group,the Voltaren group, the Decoction of Pubescent Angelica Root and Mistletoe)by random, after the experimental model of LDH were built and were successful validation by CT scan.TNF-αcontaining of serum and the surgical part,tectology changes of intervertebral disc were detect before and after the molding and later the second weeks Result:1.tectology:After the modeling, nucleus pulposus and annulus tissue lesions seen in granulation tissue ingrowth, neovascularization and inflammatory cell infiltration,by gavage Duhuojisheng soup and Voltaren, the infiltration of inflammatory cells was significantly reduced.2.blood biochemical indexes:There were statistical differences between the TNF-αcontaining of scrum in each group, after the experiment model were successfully built, and there were statistical increment in TNF-αcontaining in each group than before.The TNF-αcontaining in group the Decoction of Pubescent Angelica Root and Mistletoe and the Voltaren were dramatic decline with statistical significance,and there were statistical differences in drop-out value between the two groups,the drop-out value in group Voltaren was greater than group the Decoction of Pubescent Angelica Root and Mistletoe.Conclusion:Experemental animal model of LDH could be built by model making device.Decoction of Pubescent Angelica Root and Mistletoe have obvious therapeutic action on LDH,with the function of reducing swelling and inflammation. There were protecting function on vertebral pulp and nerve root by reducing the containing of TNF-αand other inflammatory factor in scrum and diseased region.

Related Dissertations

  1. Inhibition of RAW264.7 Macrophage Inflammatory Cytokines Release by Guggulsterone,R285
  2. Noble Dendrobium Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide and Its Mechanisms in Rats,R285.5
  3. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  4. Clinical Observation of Ditan Soup in Treating PSD,R277.7
  5. PNS treatment of rabbit lung contusion in rats,R285.5
  6. Study on Flame Retardation of PVA,TQ325.9
  7. The Expression and Inflammatory Correlation of md2 in the Brain of Rats after Inducing Severe Acute Pancreatitis,R576
  8. 1. Improvement of tmTNF-α in Insulin Resistance of Adipocytes and Its Underlying Mechanism. 2. Construction of Conserved Sequence Deleted TNF-α Mutant and the Trimerization of Remodeled TNFRBP.,R587.1
  9. Blocking TNFR Signaling Reduces the Recruitment and Migration of MDSC to Tumor Tissue,R730.3
  10. The Study of the Serum KL-6 and LDH Levels and Influential Factors in Children with Viral Pneumonia,R725.6
  11. Effect of Curcumin on Serum Levels of IL-18 in Rats Sepsis Induced by LPS,R285.5
  12. Study on Intravital Magnetic Targeted Specificity and Sustained Release Effect of Dextran-magnetic LDH-Fluorouracil Transshipment Model in Rats,R96
  13. Influence on Tumor Necrosis Factor α(TNF-α) and Inter Leukin1β and 6(IL-1β,IL-6) Extracted from Drainage Fluid after the Mammary Cancer Operation with Modified Buyanghuanwu Decoction,R737.9
  14. A Clinical Study on the Treatment of Lumber Disc Herniation(LDH) by Percutaneous Laser Disc Decomprersion (PLDD) and HUOXUETONGLUO,R681.5
  15. The Effect of Astragalus on TNF-α of Acute Kidney Injury Rats with Different Periods Fish Bile Poisoning,R285.5
  16. 1. Effect of (–)-epigallocatechin-3-gallate (EGCG) on Amino Acid Transmitters Release after Oxygen-glucose Deprivation in Primary Cultured Cortical Neurons of Rats 2. Electrophysiology Research of L-type Cav1.2 Channel on HEK-293 Transfected Cell,R285
  17. The Value of Automatic DNA Image Cytometry and Multicriteria Detection in the Diagnosis of Pleural Effusion,R734
  18. Effects of TNF-α on the Proliferantion and Differentation of Adipocyte and Toll Like Receptor-4 and Its Signaling Pathway,R589.2
  19. SR-BI Suppresses Cytotoxicity-Induced by Trivalent Iron,R543.5
  20. Observation of Therapeutic Action of Tetrandrine on Ulcerative Colitis Rats,R285.5

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile