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The Effect and Pharmacological Analysis of Houttuynia Cordata Thunb (HCT) on Diabetes Mellitus

Author: GuJuPing
Tutor: ZhengYongHua
School: Nanjing Agricultural College
Course: Food Engineering
Keywords: Houttuynia cordata Thunb Type 1 Diabetes Type 2 Diabetes blood lipids kidney fuction
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 9
Quote: 0
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Abstract


Diabetes mellitus is a kind of chronic diseases with low degree of inflammatory. Anti-inflammatory treatment has been a new method of deferring the development of diabetes and its complications.It had not been reported whether Houttuynia cordata Thunb (HCT),as one of clearing-heat and detoxification medicine,can moderate or traet diabetes and its relative complications. Working on the nosogenesis of diabetic inflammatory,and treating diabetes by the method of clearing heat and detoxification, we took Houttuynia cordata Thunb (HCT)as an example to investicate its effect on diabetes and discusse its function, which will provide nessary basis for fuctional diabetes-protective foods with Houttuynia cordata Thunb (HCT) as raw material.In order to explore the effect of therapeutic method of clearing-heat and detoxification in traditional Chinese medicine on diabetic renal complication, the study was carried out to investigate the effects of Houttuynia cordata Thunb (HCT) on lipidmetabolism and kidney function in type 1 diabetic rats. Murine type 1 diabetic model was induced by the intravenous injection of streptozotocin and the modeled rats were randomly divided into 5 groups:model group, HCT group, astragalus group, HCT add astragalus group, lotensin group, and nornlal rats without any treatment were set as normal control group. The modeled rats were treated correspondingly with distilled water, HCT, astragalus, HCT add astragalus, lotensin according their grouping for 8 weeks. Serum TC, TG, HDL-C and LDL-C levels, clearance creatinine,24h total albumin and 24hp-2 microglobin in urine were deteunined.It is suggested that Houttuynia cordata Thunb might regulate the lipid metabolism in diabetic rats, through which it could decrease the levels of TC, TG and LDL-C and increase HDL-C level. It is also implicated that HCT decoction could protect the kidney function in diabetes rats in view of its reducing the excretion of urine albumin, beta2 microglobin, and clearance rate of creatinine. It could be further inferred that Houttuynia cordata Thunb, like Astragalus mernbranaceus Bunge and lotensin, might realize its protective effects on renal function through its decreasing the high filtration, high infusion and high pern}eability of glomeruli in murine early diabetic nephropathy.To investigate the effect of Houttuynia cordata Thunb (HCT) on type 2 diabetic nephropathy怂Murine model of type 2 diabetes was induced by injecting small dose STZ and high lipid and hign glucose forage. The modeled rats were randomly divided into model, HCT, aspirin, berberine groups treated correspondongly by gastrogage for 8 weeks.HCT could regulate lipids metabolism and improve insulin sensitivity, protect kidney function.

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