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Alzheimer's disease (Alzheimer's disease, AD) is the elderly population is the most common form of dementia, and brain neurons that suffered brain plaques as the main pathological features. The brain plaques are neurotoxic, its expansion will lead to neuronal atrophy and necrosis. Studies show that the brain of amyloid plaques by Aβ peptide gradually gathered, fibrosis and other related proteins, polysaccharides such as co-precipitation formation. Metal ions Cu (Ⅱ), Zn (Ⅱ) enrichment is induced by Aβ peptide aggregation one of the reasons, and confirmed that the two metal ions with Aβ, AD has a direct relationship. Study clearly these two metal ions and Aβ peptides between the mode of action, the study of Alzheimer's disease pathogenesis and in the future to develop treatments for Alzheimer's disease drug is essential. However, since the polypeptide has a large molecular weight distribution sites and more features, for Cu (Ⅱ)-Aβ, Zn (Ⅱ)-Aβ between the coordination mode has been controversial. In this paper, synthetic analogue compounds discussed Cu (Ⅱ)-Aβ, Zn (Ⅱ)-Aβ coordination environment. The main results are summarized as follows: 1. According to the literature synthesized six imidazole ligands: bis (2 - benzimidazolyl) ethane (bbime), 2 - (aminomethyl) benzimidazole (ambmz), 2 - ammonia benzimidazole and salicylaldehyde formed by condensation Schiff base (Hsal-ambmz), 1,3 - bis (2 - benzimidazole) -1 - propylamine (bbimpa), 1,3 - bis (2 - phenyl benzimidazole) -1 - propylamine and salicyl aldehyde condensation formed Schiff base 1 - (2 - hydroxyphenyl) -2 - aza-3, 5 - bis (2 - benzimidazolyl) pentane (Hhbbimp), 2 - (2'-hydroxyphenyl) benzimidazole (Hhpbim). (2) In the above synthetic imidazole compounds as ligands, respectively, and with copper ions and zinc ions, got five copper complexes and four zinc complex and characterized by elemental analysis, UV, IR, NMR and other means for them The structures were characterized. The resulting compounds are: Cu (bbime) (NO3) 2, Cu (ambmz) 2Cl2 · H2O, Cu (sal-ambmz) Cl, Cu (bbimpa) (OAC) · 4H2O, Cu2 (hbbimp) 2 (OAC) 2 , Zn (bbime) (OAC) 2, [Zn (ambmz) 2 · H2O] Cl2 · 2H2O, Zn (bbimpa) (OAC) · 3H2O Zn (hpbim) 2 · C2H5OH. Wherein, in addition to the complex Zn (hpbim) 2 · C2H5OH and [ZnC16H18N6 · H2O] Cl2-2H2O, the other compounds have not been reported. Through the analog compounds spectroscopy comparison, we believe that under physiological conditions, copper ion and Ap peptide form 2N2O with bit patterns likely.
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