Dissertation > Excellent graduate degree dissertation topics show

Studies of the Molecular Mechanisms in the Development and Progression of Ischemic Stroke Induced by SO2 Inhalation

Author: HouLi
Tutor: SangZuo
School: Shanxi University
Course: Environmental Science
Keywords: Air pollution Sulfur dioxide SO2 Ischemic stroke Endothelial dysfunction Inflammatory response
CLC: R743.3
Type: Master's thesis
Year: 2010
Downloads: 39
Quote: 0
Read: Download Dissertation


With the continuous progress of industrialization, atmospheric pollutants, long-term low-level exposure and health problems caused by the acute pollution events is particularly prominent, has been a serious threat to human health. A large number of epidemiological results show that air pollution and stroke, and its effects are the main pollutants including SO2, NOx, O3, CO, and particulate matter. Which, SO2 in coal as its main energy in developing countries as a major air pollutants, the health effects of concern, but the current domestic and international research mainly concentrated on its correlation with respiratory diseases, as for the other tissues of the body organs the presence or absence of toxic effects is often overlooked, to determine induced effects and molecular mechanisms of stroke onset is rarely reported in the experimental conditions. Therefore, the introduction of this subject, designed to make up the blank of this field of research, the establishment of this effect detection and risk assessment of biological markers, provide a theoretical basis for the clinical treatment of health protection and pollution events. The subject first smoked by acting gas exposure to different concentrations of SO2 exposure of normal adult male Wistar rats, followed by Real-time RT-PCR technology, Western-blot technique were investigated in cerebral cortex, heart and lung in ischemic stroke-related factor endothelin -1 (ET-1), inducible nitric oxide synthase (iNOS) and cyclooxygenase -2 (COX-2), intercellular adhesion molecule -1 (ICAM -1) mRNA and protein expression changes; on the basis of the above studies, the establishment of focal cerebral ischemia reperfusion model (MCAO) rat model of low concentrations of SO2 exposure, and the effects of the exposure before and after The model rat cerebral cortex endothelial shrink factor, inflammatory factor and apoptosis-related gene expression changes. The results show that normal rat cerebral cortex in ET-1, iNOS, COX-2, ICAM-1 mRNA and protein levels of exposure with the SO2 concentration increased and increased in a dose-dependent effect; heart, lung tissue inflammation factor TNF-α, IL-1β, iNOS, ICAM-1 mRNA expression also showed the same trend, suggesting that SO2 inhalation caused the cardiopulmonary system damage induced inflammatory response, triggered after the release of inflammatory factors from entering the brain through the blood circulation system and promote ischemic injury in the brain tissue. The model Experimental results show MCAO rat brain cortex ischemic focal cerebral cortex in ischemic stroke associated factor ET-1, iNOS, COX-2, ICAM-1 expression than the sham group were significantly higher trend, caspase-3 activation, and SO2 inhalation aggravate the injury effect, thus confirming the SO2 pollution is to promote the development of the molecular mechanism of ischemic stroke, endothelial dysfunction and inflammatory responses.

Related Dissertations

  1. Application and Significance of CISS Classification and TOAST Subtype on Ischemic Stroke (Attach 210 Cases Analysis),R743.3
  2. Qingdao Industrial Atmospheric Pollution Prevention System,X51
  3. The Significance of Triggering Receptor Expressed on Myeloid Cells-1(TREM-1) in Neonatal Rats Septicemia with E.coli,R363
  4. The Influence of Omega 3 Polyunsaturated Fatty Acid on the Immune Function of Sepsis,R459.7
  5. Influence of Atrovastation on MMP-9 and TIMP-1 of Experimental Intracerebral Hemorrhage in Rats,R965
  6. Clinical Research on Integrated Treatment of TCM and Western Medicine to Acute Period of Ischemic Stroke,R743.3
  7. The Impact of DETA-NONOate on NADPH Oxidase-derived Oxidative Stress in Rats after Stroke,R743.3
  8. The Treatment of Low-dose Glucocorticoid to Severe Acute Pancreatitis: An Clinical Observation,R576
  9. Technical Support System of Case-Based Reasoning for Emergency Unexpected Air Pollution Event,X507
  10. Study on Absorption of Sulfur Dioxide and Carbon Dioxide in Aqueous Poly (Ethylene Glycol) Solutions,X701
  11. IFN-γ, IL-4 and ischemic cardiomyopathy heart failure correlation,R541.6
  12. Evaluation of the Air Pollutants Reduction During the Beijing 2008 Olympic Games,X51
  13. A Study on the Levels of CRP and S100B in Rats after Kainic Acid-Induced Seizures,R742.1
  14. Inflammatory Reaction Concerned about Acute Paraquat Poisoning and Grading System to Its Prognostic Study,R595.4
  15. Effects of Recombinant Human Erythropoietin on Microglia and Inflammatory Factors of Rat Model of Parkinson’s Disease,R742.5
  16. Value of Utilization of A-S-C-O Classification of Stroke,R743.3
  17. Clinical Value of PCT in the Adult Community-Acquired Pulmonary,R563.1
  18. Effects of Loading Dose of Atorvastatin before Percutaneous Coronary Intervention on Periprocedural Myocardial Injury,R541.4
  19. Adipose Tissue Inflammation and Expression of Lipid Droplet Associated Protein in Rat with Chronic Renal Failure,R692.5
  20. The Effect of HMGB1 to Proliferation of FLS and Expression of IL-6, IL-8 and MMP-3 in Patients of Rheumatoid Arthritis,R593.22
  21. Research on the Relationship of between Inadequate Tissue Perfusion or Inflammatory Response and Components of Excreting Insulin in the Stress Hyperglycemia of Critically Ill.,R587.1

CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
© 2012 www.DissertationTopic.Net  Mobile