Dissertation > Excellent graduate degree dissertation topics show

Synthesis of Saccharide-quinone Hybrids for the Electrochemical Probing of Specific Carbohydrate-protein Recognitions Via Cu-free Click Chemistry

Author: ZhaoHong
Tutor: ChenGuoRong；ZhuChenJiang
School: East China University of Science and Technology
Course: Pharmaceutical Engineering
Keywords: Cu-free click chemistry lectin saccharide-quinone hybrids graphene
CLC: O657.1
Type: Master's thesis
Year: 2012
Downloads: 63
Quote: 1
Read: Download Dissertation

Abstract


The application of Cu-free click cycloaddition reaction has taken our attentions in biochemistry. This reaction is simple without the addition of the catalyst and widely used in bioorthogonal chemical reaction. Lectin is a kind of specific protein which can identify and combine with saccharide in glycoprotein and glucolipid. Carbohydrate-protein interaction is the fundamental of many cellular processes, such as cell adhesion, signal transduction, immune response, proliferation and differentiation. We designed and synthesized a series of benzoquinone alkyne derivatives containing cyclooctene, constructing a series of saccharide-quinone complexves via Cu-free click cycloaddition reaction. The appliation of microwave irradiation resulted in a significant acceleration of the reactions as well as in increased yields. A highly efficient screen printed electrode was obtained by using covalent attachment between products adsorbing on the graphene oxide and the screen printed electrode. By the electrochemical probing of specific carbohydrate-protein recognitions, we will build a simple electrochemical platform to study the glycobiology.

Related Dissertations

  1. Synthesis and Study on Graphene and Co3O4/Graphene Composite about the Characteristics of Electrochemistry,O613.71
  2. Preparation of graphene Defects,O613.71
  3. WC / graphene composite electronic structure and electron transport properties,O613.71
  4. Polyethylenimine-Grafted Graphene Oxide as an Efficient Gene Delivery Vector,R450
  5. Preparation, Characterization, and Application in Polymer Composites of Graphene,TB383.1
  6. The Electronic Properties of Graphene,O481
  7. Spin-polarization and Magnetoresistance in Graphene-based Resonant-tunnelling Structures,O482.5
  8. Studies on the Application of Graphene Modified Electrodes in Electrochemical Biosensors,O657.1
  9. Study on the Preparation of Functionalized Graphene and Adsorption of Heavy Metal and Methylene Blue,O647.3
  10. First-Principles Study of Graphene for Potential Anode Materials of Lithium Ion Batteries,TM912
  11. Preparation of Surface-functionalized Graphene and Its Influence on the Mechanical Properties of Nanocomposite Materials,TB332
  12. Study on the Graphene Preparation on Cu–Ni Alloy Substrate by Chemical Vapor Deposition,O484.1
  13. Study on the Synthesis of Tio2 /graphene Composite and Its High Photocatalytic Activity for Reducing Cr（VI）,O643.36
  14. Preparation and Properties Research on Polyacrylonitrile/Graphene Oxides Compounds,TQ340.1
  15. A New Type of Structure of the Graphene Nano Device,TB383.1
  16. A Study on the Environmentally Friendly Methods for Preparation of Graphene and Its Composites,TB383.1
  17. Preparation and Characterization of Graphene/Titanate Nanotubes Photocatalysts,TB383.1
  18. Based on the two-dimensional graphene composites and preliminary application of,TB332
  19. Graphene electrode preparation and Its Electrocatalytic Performance PBDEs debromination,O613.71
  20. Graphene and other substrates SnO Arrays growth , performance and Devices,TB383.1
  21. Fe 3 O 4 , carbon nanotubes and graphene reinforced regenerated cellulose membrane research,TB383.1

CLC: > Mathematical sciences and chemical > Chemistry > Analytical Chemistry > Instrument analysis ( physics and physical chemistry ) > Electrochemical analysis
© 2012 www.DissertationTopic.Net  Mobile