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Relationship of Nitric Oxide in Serum and Microvessel Density in Human Breast Cancer and the Mechanism

Author: QiaoWanQing
Tutor: TuWei
School: China Medical University
Course: Surgery
Keywords: Breast Cancer Nitric oxide Microvessel density
CLC: R737.9
Type: Master's thesis
Year: 2010
Downloads: 17
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Abstract

Objective To investigate serum levels of nitric oxide with people breast microvascular density , and study its impact mechanisms. Fourth Affiliated Hospital of China Medical University, collected from January 2009 to February 2010 for breast cancer and 50 patients with pathologically confirmed breast surgery . Patients age 26 years old to 69 years old , with a median age of 48.91 years . Selected patients before surgery , there was no inflammation and infection, and who had no history of taking nitro - containing drugs and cancer treatment . In accordance with the standards prescribed by the AJCC Sixth Edition Cancer Staging Manual TNM staging , patients were divided into five groups . 0 7 patients , 14 cases of patients with stage Ⅰ Ⅱ patients , 13 cases , 11 cases of patients III Phase IV 5 patients . The control group were selected 10 cases of benign breast tumor patients , 10 cases of healthy women . Mining fasting blood serum NO content was measured by spectrophotometry . Postoperative take cancer tissue specimens made ??of paraffin sections . Immunohistochemical method for antibody to CD34 marker of microvascular epithelial and microvessel density . Spss analysis of variance and linear correlation analysis . Results NO content of the serum of breast cancer patients than breast benign and NO content in the serum of healthy women (P lt; 0.01), higher serum NO content of which different classification of breast cancer patients still have significant differences . NO content of 0 group and a group Ⅱ, Ⅲ, Ⅳ group . (P lt; 0.05) in serum NO content in benign breast tumor patients and healthy women with no statistical difference ( P gt ; 0.05 ) . The different stages of breast cancer patients with microvascular density there is a statistically significant difference ( P lt; 0.05 ) . In the 50 cases of breast cancer patients with different tumor grade , positive linear correlation between serum NO content and microvessel density . Concluding human serum NO content and breast cancer stage has a consistency further provides a theoretical basis for the application of its clinical tumor monitoring and early diagnosis .

Relationship of Nitric Oxide in Serum and Microvessel Density in Human Breast Cancer and the Mechanism

Abstract

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