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Objective: preventive effect of NSAIDs gastric mucosal injury observe the Yiqihuoxue square , by observing the role of of Yiqi Huoxue on serum superoxide dismutase (Super Oxide Dismutese, SOD), malondialdehyde (malondialdehyde, MDA) , to explore traditional Chinese medicine prevention mechanism of their effect targets NSAIDs gastric mucosal injury may help guide clinical better prevention NSAIDs gastric mucosal injury . Methods: taking NSAIDs 36 patients , were randomly divided into a treatment group and a control group , and randomly selected healthy group are 18 cases in each group . Oral treatment group Yiqihuoxue side of NSAIDs ( meloxicam meloxicam 7.5mg - 15mg ) (1-2 # qd) , control group I NSAIDs, both groups 15 days for a course of treatment , including NSAIDs and traditional Chinese medicine taking time treatment group are 15 days. Before and after treatment , respectively, of the two groups of patients for clinical symptoms observed , and the treatment group and the control group and the normal group hematological indices SOD, MDA in detection , and 7 days after dosing or adverse reactions fecal occult blood test checks adverse gastroscopy found in the course of treatment . Results : The symptoms of gastric mucosal injury grading quantify rated symptoms graded quantitative score was significantly worse : the control group after treatment , symptoms graded quantitative score was significantly improved in the drug treatment group . The the treatment group Yiqihuoxue square , increase SOD on increasing sexual expression , to reduce the expression of MDA , SOD expression level higher than that in control group and the treatment group , MDA expression level lower than that of the control group . Above there is a statistically significant difference . Conclusion : The role of oxygen free radical damage is an important mechanism of NSAIDs gastric mucosal injury occurred , Yiqihuoxue can only protect the gastric mucosa against oxygen radical damage, thus preventing the occurrence of NSAIDs gastric mucosal injury . Of Yiqi Huoxue Recipe by promoting the expression of antioxidant SOD , scavenging oxygen free radicals , reduce lipid peroxides MDA production , so the body from oxygen free radical damage , thus preventing the occurrence of NSAIDs gastric mucosal injury . Significance: This issue through to observe the effect of the clinical efficacy of NSAIDs gastric mucosal injury prevention , as well as traditional Chinese medicine on serum SOD , MDA 's role to explore the possible role of the target and mechanism of the Yiqihuoxue party provides a new mechanism of NSAIDs gastric mucosal injury research directions , provide new ideas for the prevention and treatment of NSAIDs gastric mucosal injury .
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