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The Effection of Podocin’s Expression about Nephrms Xiaobaikeli to Adriamycin Nephropathy Urine of Rats
Author: GaoShuQing
Tutor: ZhangPeiQing
School: Medicine Research Institute of Heilongjiang Province
Course: Chinese medical science
Keywords: Traditional Chinese medicine Adriamycin kidney disease Proteinuria Podocin
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 24
Quote: 0
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Abstract
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Objective:To test if nephritis Xiaobaikeli decreases proteinuria level in experimental animals and investigate its mechanism by biochemical and molecular biological analysis to provide the basis for its clinical application.Methods:We utilized a rat model in which nephritis is induced by one-time tail vein injection of doxorubicin.Animals were divided into five groups,namely the naive control group,model control group,Lotensin group,low-dose nephritis Xiaobaikeli group and high-dose nephritis Xiaobaikeli group.Seven weeks after treatment,we detected rat urine creatinine,proteinuria,Enzyme immunosorbent method to detect urinary albumin and Using immunohistochemistry in kidney tissues Podocin detection of expression.Results:At the end of 7-week observation,the ratio of proteinuria/urine creatinine values(P<0.05)were reduced in animals from all treatment group with doxorubicin-induced nephritis , and the high-dose nephritis Xiaobaikeli treatment had the most significant effects(P<O.05.);and the high-dose nephritis Xiaobaikeli treatment had the most significant effects (P<O . 05) ; the serum albumin concentration(P<0. 05)was increased in all treatment group; and high-dose nephritis Xiaobaikeli treatment had the most significant effects (P<0.05);and the high-dose nephritis Xiaobaikeli treatment had the most significant effects (P<0.05);the treatment by nephritis Xiaobaikeli did not affect the kidney function in rats with nephritis(P>0 . 05) ; and the high—dose nephritis Xiaobaikeli treatment had the most significant effects (P<O.05);all animals in the treatment group had attenuated foot cell damage,lower Podocin mRNA and expression in kidney tissues,and the high.dose nephritis Xiaobaikeli treatment had the most significant effects(P<0.05). Conclusion:nephritis Xiaobaikeli can reduce excretion a certain extent, in nephrotic rats and protect tubulo: It can possibly increase serum albumin level by reducing excretion;SO it can treat kidney fibrosis;It can improve the foot cell morphology of nephrotic rats,by which it reduced excretion;It can reduce Podocin mRNA and expression in kidney tissues from rats with doxorubicin.Induced nephritis,repair injured foot cell,then.reduce excretion.The therapeutic effects with high-dose nephritis Xiaobaikeli are better than low-dose nephritis Xiaobaikeli or Lotensin.
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