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Objective: To evaluate Yiqihuoxue heat method with the principle of benevolence developed precancerous lesions of stomach particle therapy clinical efficacy CAG explore benevolence stomach particles intervention GES-1 MNNG induced malignant transformation mechanism . Literature : from ancient Chinese medicine for two aspects discussed nonaggressive CAG precancerous lesions , pathogenesis, therapeutic principle understanding , recalling the modern medicine CAG precancerous lesions in molecular biology , and Helicobacter pylori (Hp) infection relationship and treatment research progress . Clinical Study: 72 cases of CAG were randomly divided into two groups of precancerous lesions , respectively, I benevolence stomach particles Weifuchun tablet , 2 courses of treatment were observed before and after treatment in patients with clinical symptoms, endoscopic signs of improvement in pathology . The results showed that : the treatment group consolidated efficacy and markedly effective rate ( clinical cure significant efficiency ) were 90.5 %, 52.4 %, significantly higher ( 63.3% , 26.7% ) , there was significant difference (P lt; 0.05); treatment the clinical symptoms effective rate was 95.2% , compared with the control group ( 83.3% ) there was a significant difference (P lt; 0.05); groups gastroscope signs have improved in the treatment group on mucosal edema, erosion improvement than the control group (P lt; 0.05); pathology groups have improved in the treatment group improved significantly on atrophy than the control group (P lt; 0.05); treatment group for the eradication of Hp infection has some effect (P lt; 0.05). Study : Using MNNG induced malignant transformation of GES-1 cells (MC cells ) as gastric precancerous lesions in vitro model of particles observed benevolence stomach rabbit serum containing the MC cell line and on Fas, Bcl-2, CDK4, P16 expression. The results showed that : benevolence stomach rabbit serum containing particles can inhibit MC cells. GES-1 cells MNNG induced malignant transformation, decreased apoptosis , Bcl-2, CDK4 expression , Fas expression was not significantly different , P16 expression decreased stomach benevolence MC particles can promote apoptosis , decreased Bcl- 2, CDK4 expression , increased Fas, P16 expression . Conclusion: benevolence stomach particles can relieve chronic atrophic gastritis in patients with clinical symptoms, improve gastric mucosal lesions , reduce glandular atrophy and inflammation, there is a certain effect on the Hp infection . Its therapeutic mechanism of action of gastric precancerous lesions may promote apoptosis of precancerous cells , regulation of the cell cycle.
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