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Carbazole ring and the imidazole ring is a ring system having a physiological activity , heterocyclic compounds with imidazole modified carbazole is possible to get a good antibacterial activity of potential drugs and pharmaceutical intermediates. In this paper, two new N- imidazole carbazole compound 9 - ((2 - methyl -1H- imidazol-1 - yl ) ethyl )-9H- carbazole, 3,6 - dichloro-9 - ( ( 2 - methyl -1H- imidazol-1 - yl ) ethyl )-9H- carbazole synthesis products were characterized by IR and NMR has been confirmed , and its antibacterial activity test . With 2 - methyl imidazole and 1,2 - dichloroethane as raw materials by N-alkylation reaction of Synthesis of 1 - (2 - chloroethyl ) - 2 - methyl imidazole, preferably obtained by orthogonal test process conditions of 1,2 - dichloroethane 2 - methylimidazole amount of substance ratio of 1:1.2 , reaction temperature 70 ℃, reaction time is 9h, the amount of solvent 15mL; under this condition, the highest yield was 43.2% . Finally, carbazole and 1 - (2 - chloro- ethyl) -2 - methyl- imidazole as raw materials by N- alkylation reaction to a new compound 9 - ((2 - methyl -1H- imidazol-1 -yl) - yl )-9H- carbazole. By carbazole 1 - (2 - chloro- ethyl) -2 - methyl imidazole orthogonal reaction experiments, the optimum reaction conditions: carbazole, 1 - (2 - chloro- ethyl) -2 - methylimidazole amount of substance ratio of 1:1.5 , the reaction temperature is 15 ℃, reaction time 6h, the amount of solvent 40mL, in this condition, the highest yield of 71.12% . With 3,6 - dichloro- carbazole 1 - (2 - chloro- ethyl) -2 - ethyl imidazole, N-alkylation reaction for synthesis of 3,6 - dichloro-9 - ((2 - methyl- -1H- imidazol-1 - yl ) ethyl )-9H- carbazole compound. Synthesis by orthogonal experiments 3,6 - dichloro-9 - ((2 - methyl -1H- imidazol-1 - yl ) ethyl )-9H- carbazole preferred reaction conditions are: 3,6 - dichloro- carbazole, 1 - (2 - chloro- ethyl) -2 - ethyl- imidazole amount of substance ratio of 1:1.5 , reaction temperature 20 ℃, reaction time 6.5h, the amount of solvent 45mL. In this reaction, the maximum yield of 73.52% . Synthesized by analyzing the two new N- imidazole compounds carbazole antibacterial activity against E. coli results showed : 3,6 - dichloro-9 - ((2 - methyl -1H- imidazol-1 - yl ) ethyl ) -9H- carbazole no antibacterial activity ; 9 - ((2 - methyl -1H- imidazol-1 - yl ) ethyl )-9H- carbazole strong antimicrobial activity , the minimum inhibitory concentration (MIC) of 0.15 mg / mL.
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