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Molecular Recognition of Supramolecular Host on Some Pharmaceutical Compounds

Author: YangJiYuan
Tutor: DuLiMing
School: Shanxi Normal University
Course: Pharmaceutical Analysis
Keywords: Sulfobutyl ether -β- cyclodextrin Palmatine Gourd [ 7 ] urea L-cystine Berberine Penicillamine Fluorospectrophotometry Fluorescent probe
CLC: R91
Type: Master's thesis
Year: 2010
Downloads: 86
Quote: 0
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Abstract


Supramolecular as the main body to explore the laws of host-guest molecule interactions and functional characteristics of groups has become in recent years, chemical, biological and pharmaceutical fields a new hotspot. This paper aims through different supramolecular host with certain packages cooperation between the guest molecules and molecular recognition studies with, the realization of certain drugs to improve the performance of molecular spectroscopy and sensitizer. Develop a high fluorescence quantum yield of drug derivative or inclusion of new species, while taking advantage of new fluorescent probe system allows certain non-fluorescent drugs to achieve fluorescence spectrometry, high sensitivity established pharmaceutical preparations and drugs in biological fluids fluorescent probe quantitative analysis methods in order to achieve some of the non-fluorescent drug pharmacokinetic studies. The content of this thesis and the results are as follows: 1, review supramolecular host cyclodextrin and CUCURBITURIL development in pharmaceutical analysis; fluorescence analysis in pharmaceutical analysis and the application of fluorescent probes in pharmaceutical analysis applications. 2, was studied by fluorescence spectroscopy, and several β-cyclodextrin-modified β-cyclodextrin inclusion complex with hydrochloric Palmatin interactions. The results show that sulfobutyl-β-cyclodextrin with palmatine 1:1 inclusion complexes can be formed, while using double reciprocal method has been the apparent binding constant. Thus, with the inclusion of this reaction was established on sulfobutyl-β-cyclodextrin in aqueous solution present high sensitivity measurement of the fluorescence method palmatine hydrochloride, the method can be used for tablets, human urine and plasma hydrochloride THP content. 3, based on the hoist palmatine hydrochloride [7] urea inclusion compounds can produce a strong fluorescence emission in acidic medium, the effects of L-cystine and the role of the inclusion complex, the results show that L-cystine can be intense fluorescence quenching of the inclusion. Established pursuant to establish a method for determining L-cystine highly sensitive fluorescent probe new method, which has been successfully used in tablets L-cystine content. L-cystine also studied with fluorescent probes palmatine inclusion competitive reaction mechanism. 4, and based on berberine gourd [7] urea inclusion compounds can produce a strong fluorescence emission, in acidic medium, penicillamine can berberine - hoist [7] urea inclusion intense fluorescence quenching. Which established a high sensitivity determination penicillamine new fluorescent probe method, which has been successfully used in tablets penicillamine content. Penicillamine also discussed with the fluorescent probe berberine inclusion competitive reaction mechanism.

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CLC: > Medicine, health > Pharmacy > Drug basic science
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