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Objective: To research and investigate the cognitive impairment and depression in patients with cerebral infarction and influence each other, and discuss the left and right hemisphere lesions on cognitive dysfunction and depression affect the situation, as well as diabetes and hypertension in patients with cerebral infarction recognized knowledge dysfunction and depression. Method: collected incidence of Chongqing Medical University, the First Affiliated Hospital of Neurology hospitalized from May 2009 to February 2010 January, 40 cases of cerebral infarction in 42 patients and the same period for the first time to the hospital health examination controls were easy to use. Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) and the Hamilton Depression Scale (HAMD), cerebral infarction and control groups of cognitive function and depressive emotional assessment, statistical analysis, and analysis of the left and right side hemisphere lesions cognitive and depressive emotional condition. Cerebral infarction, cerebral infarction group were divided into combined depression group (PSD) Unconsolidated depression group (non-PSD), the results of the comparison between the two groups MMSE, MoCA score based on the HAMD the score results. Depending on whether the merger of hypertension, cerebral infarction patients in patients with hypertension and non-hypertension group, the comparison between the two groups above Scale (MMSE, MoCA, HAMD) score results. Whether diabetes, cerebral infarction group were divided into diabetic group and nondiabetic group, the comparison between the two groups above Scale (MMSE, MoCA, HAMD) score. Results: 1, in patients with cerebral infarction group 42 cases, including 24 cases, 18 cases of the right side of the left hemisphere infarction group; the PSD group of 13 patients, 29 cases of non-PSD group; combined hypertension in 23 cases, 19 cases of non-hypertension; diabetes mellitus 17 cases, 25 cases of non-diabetic; 40 cases and the control group; cerebral infarction in each group and the control group in terms of gender, age, education level by t-test and χ2 test, the difference was not statistically significance (p gt; 0.05). 2, in patients with cerebral infarction group MMSE score compared to 27.33 ± 2.77, 24.31 ± 5.43, with the control group, the difference was statistically significant (p lt; 0.05); 42 cases of cerebral infarction patients according to the level of education of different sub ≤ MMSE The limit values ??of 20 cases, the MMSE screening for the first time after cerebral infarction in patients with cognitive impairment occurred was 47.6%. Cerebral infarction patients MoCA score was 21.55 ± 6.43, compared with the control group, 27.24 ± 2.27, the difference was statistically significant (p lt; 0.05); patients with cerebral infarction group score ≤ 26 points, with 27 cases, that is, for the first time cerebral infarction After patients with cognitive impairment was 64.3%. Cerebral infarction patients HAMD score 1.76 ± 1.92 to 5.29 ± 3.89, and the control group, the difference was statistically significant (p lt; 0.05), in patients with cerebral infarction group HAMD score ≥ 8 points, 13 cases, that is, for the first time after cerebral infarction in patients with depression was 31.0%. 3, the left hemisphere lesion group MMSE score of 23.92 ± 4.46, and the right hemisphere lesion group compared to 24.83 ± 6.56, the difference was not statistically significance (p gt; 0.05); the MoCA score left hemisphere lesion group was 19.63 ± 6.37, and right 24.11 ± 5.71 compared difference was statistically significant (p lt; 0.05); HAMD score the left hemisphere lesion group was 6.71 ± 3.58, 3.39 ± 3.45 and the right, the difference had statistical significance (p lt; 0.05) . PSD group MMSE score was 21.00 ± 4.51, compared with non-PSD group 25.79 ± 5.16, the difference was statistically significant (p lt; 0.05); the the MoCA score PSD group was 15.62 ± 5.90, and non-PSD group 24.21 ± 4.69 compare the difference was statistically significant (p lt; 0.05), and the PSD group cognitive scores than non-PSD group is low. The hypertension group MMSE score was 24.48 ± 5.48, 24.11 ± 5.57 compares with the non-hypertensive group, the difference was not statistically significance (p gt; 0.05); the MoCA score hypertension disease group was 21.35 ± 7.00, and non-high blood pressure disease group compared to 21.79 ± 5.85, the difference was not statistically significant (p gt; 0.05); the HAMD score hypertension group to 5.48 ± 3.88, 5.05 ± 3.92 and non-hypertension group, the difference was not statistically significant (p gt; 0.05). 6 diabetic group MMSE score was 22.29 ± 4.25, compared with non-diabetic group 25.68 ± 5.74, the difference was statistically significant (p lt; 0.05); the MoCA score diabetic group was 16.94 ± 6.21, compared with non-diabetic group 24.68 ± 4.43, The difference was statistically significant (p lt; 0.05); The HAMD score diabetic group was 7.71 ± 4.01, compared with non-diabetic group, 3.64 ± 2.78, the difference was statistically significant (p lt; 0.05) and diabetic group cognitive scores compared with non-diabetic group, low, and high HAMD score. Conclusion: cerebral infarction in patients with cognitive impairment and depressive emotional obstacles to the high incidence of, and are left hemisphere lesions significantly. After cerebral infarction in patients with cognitive impairment and depressive affective disorder often occur at the same time, both mutual relationship, severely reducing the therapeutic effect and quality of life of patients with cerebral infarction. Diabetic patients with cerebral infarction cognitive dysfunction and depressive affective disorder is significantly higher. Hypertension no significant effect on cognitive and depressive affective disorder patients with cerebral infarction.
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